穿透素3与冠心病关系的研究进展

Research Progress of the Relationship Between Pentraxin 3 and Coronary Heart Disease

穿透素3是炎症急性期的反应蛋白,同时作为可溶性模式识别受体,通过参与补体途径,调节炎症反应,影响动脉粥样斑块的稳定性。基础研究和临床研究显示穿透素3在调节动脉粥样硬化性心血管疾病中可能有重要作用,作为心血管不良事件的预测因子近年受到了广泛关注。

Pentraxin 3（PTX3）is a reactive protein in the acute phase of inflammation.At the same time,PTX3 acts as a soluble pattern recognition receptor and regulates the inflammatory response by participating in the complement pathway,thereby affecting the stability of atherosclerotic plaque.In addition,the basic research and clinical studies have shown that PTX3 may plays an important role in the regulation of atherosclerotic cardiovascular disease.PTX3,as a predictor of cardiovascular events,has received widespread attention in recent years.