Glymphatic系统与认知障碍相关疾病的研究进展

Advances in glymphatic system and cognitive impairment related diseases

Glymphatic系统通过脑脊液和脑间质液之间的引流与物质交换使得脑内代谢废物被快速清除,影响因素包括AQP-4、脑动脉搏动、睡眠及体位等。Glymphatic系统功能障碍可导致多种认知障碍相关疾病发生,促使其功能恢复可能是防治认知障碍相关疾病的新思路。

The glymphatic system rapidly removes metabolic waste in the brain through the drainage and material exchange between cerebrospinal fluid and interstitial fluid. The influencing factors include AQP- 4, cerebral artery pulse, sleep and body posture. Glymphatic system dysfunction leads to a variety of diseases related to cognitive impairment. Glymphatic system function recovery may be a new way to prevent and treat diseases related to cognitive impairment.