川芎联合酮咯酸氨丁三醇对慢性颈肩腰腿痛患者氧化应激的影响

Effects of Rhizoma Ligustici Chuanxiong Combined with Ketorolac Tromethamine on Oxidative Stress in Patients with Chronic Neck and Shoulder Pain

目的:探讨川芎联合酮咯酸氨丁三醇对慢性颈肩腰腿痛患者氧化应激的影响。方法:选取2017年2月至2018年2月青海大学附属医院收治的慢性颈肩腰腿痛患者152例,按照数字表法随机分为2组。对照组76例给予酮咯酸氨丁三醇治疗,观察组76例在对照组基础加用川芎治疗。比较2组患者临床疗效、疼痛视觉模拟评分法(VAS)评分、现有疼痛强度(PPI)评分的差异,并分析患者超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)水平及Barthel评分的变化;结果:观察组患者治愈率、总有效率分别为30.3%和90.8%,高于对照组的13.2%和77.6%,差异有统计学意义(P<0.05);治疗2周后、治疗4周后观察组患者VAS评分、PPI评分均显著降低,也低于同期对照组(P<0.05);治疗2周后、治疗4周后观察组患者MDA水平显著降低,也低于同期对照组,差异有统计学意义(P<0.05);治疗2周后、治疗4周后观察组患者SOD、GSH-PX水平显著升高,也高于同期对照组(P<0.05);治疗2周后、治疗4周后观察组患者Barthel评分显著升高,也高于同期对照组,差异有统计学意义(P<0.05);结论:川芎联合酮咯酸氨丁三醇对慢性颈肩腰腿痛临床效果好,具有较高的临床有效率,能显著改善患者疼痛状态及氧化应激状态,日常生活能力也较高。

Objective： To explore the effects of Rhizoma Ligustici Chuanxiong combined with ketorolac tromethamine on the level of oxidative stress in patients with chronic neck and shoulder pain.Methods： The 152 patients with chronic neck and shoulder pain treated in our hospital from February 2017 to February 2018 were randomly divided into two groups according to the digital table method.In the control group,76 patients were treated with ketorolac tromethamine,and 76 patients in the observation group were treated with Rhizoma Ligustici Chuanxiong on the basis of the control group.The clinical efficacy,pain visual analogue（ VAS）score,and present pain intensity（ PPI） scores were compared between the two groups.Patients were also analyzed for superoxide dismutase（ SOD） and glutathione peroxidase（ GSH-PX）,malondialdehyde（ MDA） levels and Barthel score changes.Results：The curative rate and total effective rate were 30.3% and 90.8% in the observation group,which were higher than the control group of 13.2% and 77.6%,respectively,with statistically significant difference（ P〈0.05）.After 2 weeks and 4 weeks of treatment,the levels of VAS score and PPI score were significantly lower in the observation group,which was also lower than that of the control group at the same time,with statistically significant difference（ P〈0.05）.After 2 weeks and 4 weeks of treatment,the levels of MDA were significantly lower in the observation group,which was also lower than that of the control group at the same time with statistically significant difference（ P〈0.05）.After 2 weeks and 4 weeks of treatment,the levels of SOD and GSH-PX were significantly higher in the observation group,which was also higher than that of the control group at the same time,with statistically significant difference（ P〈0.05）.After 2 weeks and 4 weeks of treatment,the levels of Barthel score were significantly higher in the observation group,which was also higher than that of the control group at the same time,with statistically significant difference（ P〈0.05）.Conclusion： Rhizoma Ligustici Chuanxiong combined with ketorolac tromethamine has a good clinical effect on chronic neck and shoulder pain.It has high clinical efficiency,significantly improves the patient＇s pain state and oxidative stress,and has higher daily life ability.It is worthy of clinical choice.