加味温胆汤治疗痰湿内阻型慢性精神分裂症的临床效果

Clinical Study on Jiawei Wendan Decoction in Treating Chronic Schizophrenia with Phlegm Dampness Type

目的:探讨加味温胆汤治疗痰湿内阻型慢性精神分裂症的临床效果。方法:选取2014年12至2016年12月广州医科大学附属脑科医院收治的慢性精神分裂症患者84例,按照随机表法分为观察组与对照组,每组42例。对照组口服奥氮平片,观察组在对照组基础上应用加味温胆汤治疗。2组疗程均为6周。比较2组治疗疗效,治疗前后PANSS评分、LOTCA评分、HAMA评分、HAMD评分、Hcy和SOD水平变化,以及不良反应发生情况。结果:观察组治疗总有效率(90.48%)高于对照组(71.43%)(P<0.05);与治疗前比较,2组治疗后PANSS评分降低而LOTCA评分增加(P<0.05);观察组治疗后PANSS评分低于对照组而LOTCA评分高于对照组,差异有统计学意义(P<0.05);2组治疗后HAMA评分和HAMD评分降低,差异有统计学意义(P<0.05);观察组治疗后HAMA评分和HAMD评分低于对照组,差异有统计学意义(P<0.05);2组治疗后血清Hcy水平降低而SOD水平增加,差异有统计学意义(P<0.05);观察组治疗后血清Hcy水平低于对照组而SOD水平高于对照组(t=9.002、14.957,P<0.05);观察组不良反应发生率(11.90%)低于对照组(33.33%),差异有统计学意义(P<0.05)。结论:加味温胆汤治疗痰湿内阻型慢性精神分裂症的临床疗效显著。

Objective： To investigate the clinical effect of modified Wendan Decoction in treating chronic schizophrenia with phlegm dampness type.Methods： A total of 84 patients with chronic schizophrenia admitted in our hospital from December 2014 to December 2016 were randomly divided into observation group（ n = 42） and control group（ n = 42）.The control group was treated with Olanzapine Tablets,while the observation group was treated with Jiawei Wendan Decoction on the basis of the control group.Two groups were treated for 6 weeks.The therapeutic effects of the two groups were compared before and after treatment.The PANSS score,LOTCA score,HAMA score,HAMD score,Hcy and SOD levels were observed before and after treatment.Results： The total efficiency of the observation group（ 90.48%） was higher than the control group（ 71.43%）（ P〈0.05）; after treatment,PANSS scores decreased and LOTCA scores increased（ observation group t = 47.623,30.606,control group t =29.912,16.134,P〈0.05）; after treatment,PANSS score of the observation group was lower than that of control group and LOTCA score was higher than the control group（ t = 16.252,12.684,P〈0.05）; the HAMA score and HAMD score decreased in two groups after treatment（ observation group t = 37.449,35.239,control group t = 25.738,26.646,P〈0.05）; after treatment,HAMA score and HAMD score of observation group were lower than the control group（ t = 11.270,8.867,P〈0.05）; the serum Hcy levels of the two groups after treatment decreased,and SOD level increased（ the observation group t = 15.991,24.989,control group t = 7.283,11.239,P〈0.05）; the serum Hcy levels after treatment in the observation group were lower than in the control group and the level of SOD was higher than that of control group（ t = 9.002,14.957,P〈0.05）; the incidence of adverse reactions in the observation group（ 11.90%） was lower than that in the control group（ 33.33%）（ P〈0.05）.Conclusion： The clinical effect of Jiawei Wendan Decoction in treating chronic schizophrenia with phlegm dampness type is significant,and it has important research value.