地黄萸苓方治疗痛风性关节炎患者的临床疗效及对血清炎性因子的影响

Clinical Efficacy of Dihuang Yuling Decoction in the Treatment of Patients with Gouty Arthritis and Effects on Serum Inflammatory Cytokines

目的:探讨地黄萸苓方治疗痛风性关节炎患者的临床疗效及对血清炎性因子的影响。方法:选取2015年12月至2017年3月广州中医药大学附属骨伤科医院收治的痛风性关节炎患者104例,按照随机数字表法分为观察组和对照组,每组52例。对照组采用西医治疗,观察组在对照组基础上结合地黄萸苓方治疗。2组疗程均为14 d。比较2组治疗疗效,主要症状积分、红细胞沉降率和血尿酸变化、血清炎性因子变化。结果:观察组总有效率(96.15%)高于对照组(75.00%)(P<0.05)。2组治疗后关节发热、关节肿胀、关节疼痛积分降低(P<0.05);观察组治疗后关节发热、关节肿胀、关节疼痛积分低于对照组(P<0.05)。2组治疗后红细胞沉降率和血尿酸降低(P<0.05);观察组治疗后红细胞沉降率和血尿酸低于对照组(P<0.05)。2组治疗后IL-1β、IL-6和IL-8降低(P<0.05);观察组治疗后IL-1β、IL-6和IL-8低于对照组(P<0.05)。结论:地黄萸苓方治疗痛风性关节炎患者的临床疗效明显,且可降低血清炎性因子IL-1β、IL-6和IL-8水平。

Objective： To investigate the clinical effects of Dihuang Yuling Decoction in the treatment of patients with gouty arthritis and effects on serum inflammatory cytokines.Methods： A total of 104 cases of gouty arthritis admitted to our hospital from December 2015 to March 2017 were randomly divided into the observation group（ 52 cases） and the control group（ 52 cases）.The control group was treated with western medicine,and the observation group was added Di Huang Yuling Decoction.The two groups were treated for 14 d.The therapeutic effects of the two groups were compared,and the main symptom scores,ESR,serum uric acid and serum inflammatory cytokines were measured before and after treatment.Results： The total effective rate of the observation group（ 96.15%） was higher than that of the control group（ 75.00%）（ P〈0.05）.Joint fever,joint swelling,joint pain scores decreased after treatment in two groups（ P〈0.05）; fever,joint swelling,joint pain score of the observation group after treatment were lower than the control group（ P〈0.05）.ESR and blood uric acid decreased in two groups after treatment（ P〈0.05）; ESR and blood uric acid of the observation group after treatment were lower than the control group（ P〈0.05）.IL-1,IL-6 and beta IL-8 decreased in two groups after treatment（ P〈0.05）; IL-1β,IL-6 and IL-8 of patients in the observation group were lower than the control group（ P〈0.05）.Conclusion： The clinical curative effect of Dihuang Yuling Decoction in the treatment of patients with gouty arthritis is significantly,and can reduce the serum inflammatory cytokines IL-1β,IL-6 and IL-8 level with important research significance.