中药穴位贴敷辅助治疗轮状病毒肠炎疗效观察

Effect of acupoint application of traditional Chinese medicine on the adjuvant treatment of rotavirus enteritis

目的探讨中药穴位贴敷辅助治疗轮状病毒肠炎患者的临床效果及安全性。方法回顾性分析2016年1月至2017年12月期间在广州市花都区妇幼保健院儿科治疗的92例轮状病毒肠炎患者的临床资料,根据治疗方案不同分为对照组和观察组,每组46例。两组患儿均给予常规对症支持治疗,对照组同时采用布拉氏酵母菌散联合蒙脱石散剂治疗,观察组则在对照组基础上联合中药穴位贴敷辅助治疗,两组均连续治疗7 d,治疗后比较两组患儿的临床疗效、不良反应及白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)等炎症因子水平情况。结果观察组和对照组患儿治疗7 d后脱水纠正时间[(2.26±0.83)d vs(4.09±0.94)d]、退热时间[(1.69±0.64)d vs(3.42±0.79)d]、腹痛时间[(3.21±0.86)d vs(5.66±0.93)d]、止血时间[(3.15±0.85)d vs(5.69±0.91)d]及大便恢复正常时间[(4.36±0.96)d vs(7.49±1.32)d]比较,观察组均短于对照组,差异均有统计学意义(P<0.05);观察组和对照组患儿治疗7 d后的IL-6[(7.89±2.15)pg/m L vs(18.53±3.09)pg/m L]、IL-10[(4.68±0.96)pg/m L vs(19.43±1.57)pg/m L]、TNF-α[(13.43±2.83)pg/m L vs(25.59±3.12)pg/m L]、CRP水平[(1.04±0.94)mg/L vs(4.35±1.12)mg/L]比较,观察组均低于对照组,差异均有统计学意义(P<0.05);而两组患儿治疗期间的皮肤过敏、顽固性便秘、口干、发热等不良反应发生率比较差异均无统计学意义(P>0.05)。结论将中药穴位贴敷辅助用于轮状病毒肠炎患者的治疗,不仅有助于缩短症状改善时间,降低炎症因子水平,而且安全性较高,值得推广应用。

Objective To explore the clinical effect and safety of acupoint application of traditional Chinese medicine in the adjuvant treatment of patients with rotavirus enteritis. Methods The clinical data of 92 patients with rotavirus enteritis treated in Department of Pediatrics, Guangzhou Huadu District Maternal and Child Health Hospital, Guangzhou city from January 2016 to December 2017 were retrospectively analyzed. The patients were divided into the observation group and control group according to different treatment options, with 46 cases in each group. The patients in the two groups were given conventional support treatment. The control group was treated simultaneously with brady＇s yeast powder combined montmorillonite powder treatment, and the observation group was treated additionally with traditional Chinese medicine acupoint sticking auxiliary treatment on the base of the treatment of the control group. The treatment course of both groups was 7 days. The patient＇s clinical curative effect, adverse reaction, interleukin 6（IL-6）, interleukin 10（IL-10）, tumor necrosis factor alpha（TNF-α）, C-reactive protein（CRP） and the levels of other inflammatory factors of the two groups were compared. Results After 7 days of treatment, the dehydration correct time, antifebrile time, abdominal pain of time, hemostatic time and defecate normal time in the observation group were（2.26±0.83） d,（1.69±0.64） d,（3.21±0.86） d,（3.15 ± 0.85） d,（4.36 ± 0.96） d, respectively, which were significantly shorter than corresponding（4.09 ± 0.94） d,（3.42 ± 0.79） d,（5.66 ± 0.93） d,（5.69 ± 0.91） d,（7.49 ± 1.32） d in the control group（all P〈0.05）. The levels of IL-6,IL-10, TNF-α, CRP in the observation group were（7.89 ± 2.15） pg/m L,（4.68 ± 0.96） pg/m L,（13.43 ± 2.83） pg/m L,（1.04 ± 0.94） mg/L, respectively, which were significantly lower than corresponding（18.53 ± 3.09） pg/m L,（19.43 ±1.57） pg/m L,（25.59±3.12） pg/m L,（4.35±1.12） mg/L in the control group（all P〈0.05）. However, there was no significant difference between the two groups during the treatment in the incidence of adverse reactions including skin allergy, intractable constipation, dry mouth and fever（P〉0.05）. Conclusion The acupoint application of traditional Chinese medicine in the adjuvant treatment of patients with rotavirus enteritis can not only shorten the time for improvement of symptoms and reduce the level of inflammatory factors, but also has high safety, which is worthy of promotion and application.