CHE水平与ACS的临床分型以及冠状动脉狭窄程度的相关性

Correlation between CHE level and clinical classification of ACS and the degree of coronary artery stenosis

目的研究血清胆碱酯酶(CHE)水平与急性冠状动脉综合征(ACS)的临床分型以及冠状动脉狭窄程度的相关性。方法将该院心血管内科2015年8月至2016年8月诊断为ACS的患者300例作为研究对象。根据ACS的类型分为3组:不稳定性心绞痛组(UAP组,n=100)、非ST段抬高型急性心肌梗死组(NSTEMI组,n=98)、ST段抬高型急性心肌梗死组(STEMI组,n=102)。根据冠状动脉狭窄程度分为3组:轻度狭窄组、中度狭窄组和重度狭窄组。记录所有患者的一般资料,检测生化指标及血清CHE水平,并进行统计分析。结果 UAP组、NSTEMI组、STEMI组的血清CHE水平依次升高,3组间差异有统计学意义(P<0.05)。轻度狭窄组、中度狭窄组和重度狭窄组的血清CHE水平也呈现升高的趋势,3组间差异有统计学意义(P<0.05)。生化指标中,各组患者中低密度脂蛋白和高密度脂蛋白水平差异均有统计学意义(P<0.05)。低密度脂蛋白和血清CHE是ACS分型以及冠状动脉狭窄的相关危险因素。血清CHE与ACS分型呈正相关(r=0.135,P=0.019),血清CHE与冠状动脉狭窄程度也呈正相关(r=0.154,P=0.008)。结论血清CHE水平与ACS的临床分型以及冠状动脉狭窄程度具有相关性,能够在一定程度上反映ACS类型和冠状动脉狭窄程度。

Objective To study the correlation between serum cholinesterase （CHE） level and the clinical classification of ACS and the degree of coronary artery stenosis. Methods Totally 300 patients diagnosed as ACS from August 2015 to August 2016 in the Department of Cardiology in our hospital were selected as the research objects.According to the type of ACS,all patients were divided into three groups：the unstable angina group （UAP group, n =100）,the non ST segment elevation acute myocardial infarction group （NSTEMI group, n =98）,and the ST elevation acute myocardial infarction group （STEMI group, n =102）.According to the degree of coronary stenosis,all patients were divided into three groups：mild stenosis group,moderate stenosis group and severe stenosis group.The general data of all patients were recorded,biochemical indexes and serum CHE levels were detected and statistical analysis was carried out. Results The level of serum CHE in UAP group,NSTEMI group and STEMI group increased in turn,and the difference between the three groups was statistically significant （ P 〈 0.05 ）.The level of serum CHE in the mild stenosis group,the moderate stenosis group and the severe stenosis group also showed a rising trend,and the difference between the three groups was statistically significant （ P 〈0.05）.In the biochemical indexes,the levels of low density lipoprotein（LDL） and high density lipoprotein （HDL） were different in all the patients （ P 〈0.05）.LDL and serum CHE were associated risk factors for ACS typing and arterial stenosis.There was a positive correlation between the serum CHE level and the ACS typing （ r =0.135, P =0.019）,and the serum CHE level was also positively correlated with the degree of coronary stenosis （ r =0.154, P =0.008）. Conclusion The level of serum CHE is correlated with the clinical classification of ACS and the degree of coronary artery stenosis.It can reflect ACS type and degree of coronary artery stenosis to a certain extent.