肝硬化患者CG、RDW与NLR水平变化及临床意义

Changes and clinical significance of CG,RDW and NLR levels in patients with liver cirrhosis

目的观察肝硬化患者甘胆酸(CG)、红细胞分布宽度(RDW)和中性粒细胞与淋巴细胞比值(NLR)变化,并探讨其临床意义。方法 91例肝硬化患者按Child-Pugh分级标准分为A级43例,B级27例,C级21例,另随机选取94例体检健康者作为健康对照组。检测各组CG水平、RDW、中性粒细胞的绝对数目和淋巴细胞的绝对数目,计算NLR。并分析各指标之间的相关性。结果肝硬化组CG、RDW和NLR均高于健康对照组(P<0.05);不同Child-Pugh分级肝硬化组3项指标比较,差异有统计学意义(P<0.05),随级别升高均显著升高(P<0.05);91例肝硬化患者中CG、RDW与NLR间均互呈正相关关系(P<0.05)。结论肝硬化患者CG、RDW和NLR升高,检测其对临床辅助诊断肝硬化及不同Child-Pugh分级具有重要的临床意义。

Objective To observe the changes of CG,RDW and NLR in the patients with liver cirrhosis and to explore its clinical significance. Methods According to Child-Pugh grading standard,91 patients with liver cirrhosis were divided into grade A（ n =43）,grade B（ n =27） and grade C（ n =21）,and 94 healthy subjects were randomly selected as healthy control group.The levels of CG,RDW,the absolute number of neutrophils and the absolute number of lymphocytes were measured,and NLR was calculated.And the correlation between the indexes was analyzed. Results CG,RDW and NLR in liver cirrhosis group were higher than those in healthy control group （P〈0.05）.There was a significant difference in the 3 indexes in different Child-Pugh grading liver cirrhosis groups （ P 〈0.05）,which increased significantly as the level increased （ P 〈0.05）.There was a positive correlation between CG,RDW and NLR in 91 patients with liver cirrhosis （P〈0.05）. Conclusion The levels of CG,RDW and NLR in patients with liver cirrhosis are increased,and the detection is of important clinical significance in the clinical diagnosis of liver cirrhosis and different Child-Pugh grades.