当归补血汤对冠状动脉搭桥术后患者心肌功能及血清IL-38水平的影响

Effect of Danggui Buxue decoction on myocardial function and serum IL-38 level in patients with postoperation coronary artery bypass grafting

目的探讨当归补血汤对冠状动脉搭桥术后患者心肌功能及血清IL-38水平的影响。方法将我院行冠状动脉搭桥术的60例患者分为研究组与对照组,各30例。对照组给予常规治疗,研究组在对照组基础上给予当归补血汤治疗。比较两组患者临床疗效、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、白细胞介素-38(IL-38)水平及用药不良反应发生情况。结果研究组治疗总有效率(83.33%)与对照组(66.67%)无统计学差异(P>0.05)。治疗后,两组患者的CK-MB、cTnI、IL-38水平均显著低于治疗前,且研究组低于对照组(P<0.05)。用药后两组患者均未出现明显不良反应,肝肾功能检测正常。结论在常规治疗的基础上联合当归补血汤治疗脉粥样硬化性心脏病临床效果显著,可改善冠状动患者心肌功能,可临床推广应用。

Objective To investigate the effect of Danggui Buxue decoction on myocardial function and serum IL-38level in patients with postoperation coronary artery bypass grafting. Methods A total of 60 patients undergoing coronaryartery bypass grafting in our hospital were divided into study group and control group, with 30 cases in each group. Thecontrol group received routine treatment, and the study group was treated with Danggui Buxue decoction on the basis of thecontrol group. The clinical efficacy, the levels of creatine kinase isoenzyme （CK-MB）, cardiac troponin I （cTnI）, interleukin-38 （IL-38） and adverse drug reactions of the two groups were compared. Results There was no significant difference in thetotal effective rate of treatment between the study group （83.33%） and the control group （66.67%, P〉0.05）. After treatment,the levels of CK-MB, cTnI and IL-38 of the two groups were significantly lower than those before treatment, and those ofthe study group were lower than the control group （P〈0.05）. There was no significant adverse reactions between the twogroups, and the liver and kidney function were normal. Conclusion The combination of Danggui Buxue decoction on thebasis of routine treatment has a satisfactory clinical effect in coronary atherosclerotic heart disease, can improve themyocardial function of patients, which can be popularized and applied in clinic.