多原发乳腺癌的临床流行病学特征——82例患者的回顾性研究

Multiple primary cancers associated with breast cancer:A retrospective analysis of 82 cases

目的:采用回顾性分析研究,探讨乳腺癌同时或异时合并其他部位原发癌患者的临床流行病学特征。方法:通过病例检索系统,统计2006年1月至2016年12月空军军医大学(原第四军医大学)唐都医院收治的"多原发癌"共计933例,经病例回顾及进一步筛选,共计82例纳入本研究,对纳入研究的乳腺癌合并其他原发肿瘤的临床特点及流行病学特征进行分析。结果:乳腺癌患者约占多原发癌住院患者8.79%(82/933),中位发病年龄56岁(23~81岁),以合并肺癌、卵巢癌、甲状腺癌、结直肠癌最常见。合并感染及代谢性疾病的约占17.07%,有乳腺癌家族史的约占18.30%。在发病年龄方面,<50岁的乳腺癌患者其第一原发癌与第二原发癌的中位间隔时间为2.4年;对于≥50岁的多原发癌患者,其发病中位间隔8.5年。结论:探讨乳腺癌同时或异时合并其他部位原发癌患者的临床流行病学特征,有利于减少临床误诊率及降低第二肿瘤的发病率。

Objective：To investigate clinical characteristics of multiple primary cancers （MPC） of breast cancers to provide reference for following study of secondary primary tumor and （or） MPC. Methods：The clinical data of mul-tiple primary cancers of 82 breast cancer adnfitted from January 2006 to December 2016 in Tangdu hospital were re-viewed. Results ： The nfiddle on diagnose age of the 1 st primary cancer was 56 （ 23 - 81 ） years old. Lung cancer, ovari-an cancer, thyroid cancer and colorectal cancer were the most common types of tumors in MPC involving breast canc-ers. Overall, 17.07% of cases were diagnosed with conconfitant disease, 18.30% of cases with family history. In the subgroup analysis revealed that the nfiddle interval time was 2.4 years in younger group （ 〈 50 years old ） , but 8.5 years in older group（ ≥50 years old）. Conclusion：The epidenfiology characteristic of MPC should be studied further in order to reduce the misdignosis and the risk for second cancers.