孕期和生命早期减盐对心血管健康的深远影响

Profound effect of reducing salt intake on cardiovascular health in pregnancy and early life

高血压是心血管疾病最重要的危险因素之一。钠盐摄取是高血压的重要环境因素,全民减盐是推动中国高血压防治进程的重要策略,关乎全民心血管健康。在一些特殊时期,尤其是孕期和生命早期的减盐,对母子两代远期的心血管健康具有深远影响。高盐会激活母体氧化应激、增加肾素-血管紧张素-醛固酮系统活性,造成水钠潴留,增加妊娠期高血压的发生风险。孕期高盐对于子代的血管功能遗传编程的影响独立于子代出生后的盐饮食环境和血压改变。

Hypertension is one of the most important risk factors of cardiovascular disease. Sodium intake is an important environmental factor of hypertension. Reduction of salt intake is an important strategy to prevent hypertension and promote cardiovascular health of Chinese. In some special period, especially in pregnancy and early life, salt reduction has a profound e？ect on long-term cardiovascular health both for the mothers and their o？springs. High salt intake increases maternal oxidative stress, the activity of renin-angiotensin-aldosterone system, cause water-sodium retention and eventually increase the risk of hypertensive disorders of pregnancy. The e？ect of high salt intake during pregnancy on the genetic programming of vascular function in o？spring is independent of salt diet environment after birth.