D-乳酸与I-FABP在肠屏障功能受损中作用的研究进展

Research progress of D-lactic acid and I-FABP in impaired intestinal barrier function

肠道是人体消化吸收的器官,同时具有对肠道细菌及其毒素阻挡入侵的屏障作用。在手术、感染、休克、创伤等应激下肠黏膜最易受损,当其受损后,将会造成一系列的病理生理变化,甚至导致系统性炎症反应综合征(SIRS)和多器官功能不全综合征(MODS)的发生,给患者带来难以承受的不良结局。因此早期预警肠黏膜屏障功能对于预防肠黏膜屏障功能受损导致的临床不良结局就显得尤为重要。目前国内外学者报道了许多与肠黏膜屏障受损相关的标志物,并将其用于临床评估。该文对D-乳酸和I-FABP在肠屏障功能受损中作用的研究进展进行综述。

The intestinal tract is the digestion organ of human body, which has a barrier to the intestinal bacteria and their toxins. The intestinal mucosas are most vulnerable to stresses, such as trauma, infection, shock and surgery. If the intestinal mucosas are damaged, they will cause a series of pathophysiological changes, even leading to the occurrence of systemic inflammatory response syndrome（SIRS） and multi-organ dysfunction syndrome（MODS） which would result in an unbearable outcome for the patients. Early warning of the intestinal mucosal barrier function is very important for preventing the clinical adverse events of the intestinal mucosal barrier function.At present, domestic and foreign scholars have reported many markers related to the damage of intestinal mucosal barrier and hope that they can be used to predict severity and prognosis in the patients clinically. In this paper, we review the research progress of D-lactic acid and I-FABP in the impaired intestinal barrier function.