养真生发酊治疗斑秃的临床观察

Clinical Effect of Yangzhen Shengfa Tincture in Treatment of Alopecia Areata

目的观察养真生发酊治疗斑秃的临床疗效。方法将60例符合纳入标准的斑秃患者随机分为2组,治疗组和对照组各30例,治疗组采用养真生发冲剂口服与养真生发酊外涂联合治疗,对照组采用养真生发冲剂口服配合米诺地尔酊外涂治疗,2组均治疗2个疗程(3个月为1疗程)后判定疗效。结果两组治疗后较治疗前秃发严重程度评分(SALT评分)均有降低(P<0.01),且治疗组评分明显低于对照组(P<0.05);治疗组总有效率为90.0%,对照组为76.6%,两组比较差异有统计学意义(P<0.05)。结论养真生发冲剂内服联合养真生发酊外涂治疗斑秃疗效确切,且中药养真生发酊外治疗效优于米诺地尔酊,值得临床应用。

Objective To investigate the clinical etteet of Yangzhen Shengfa Tincture in the treatment of alopeeia areata. Methods A total of 60 patients with alopeeia areata who met the inclusion criteria were randomly divided into control group and treatment group, with 30 patients in each group. The patients in the treatment group were treated with oral Yangzhen Shengfa Granule and external application of Yangzhen Shengfa Tineture, and those in the control group were treated with oral Yangzhen Shengta Granule and external application of minoxidil tineture. Each course of treatment was 3 months, and both groups were treated for 2 courses. Clinical outcome was assessed. Results Both groups had a significant reduction in Severity of Alopeeia Tool score after treatment （P〈0.01）, and the treatment group had a significantly greater reduction than the control group P〈0.05）. There was a significant ditterenee in overall response rate between the treatment group and the control group （90% vs 76.6%,P〈0.05）. Conclusion Oral Yangzhen Shengfa Granule and external application of Yangzhen Shengta Tinetm＇e have a good clinical effect in the treatment of alopeeia areata, and Yangzhen Shengfa Tinetre is more effective than minoxidil tineture in external application. Theretore, this treatment holds promise for clinical application.