冠心病血瘀证与DNA甲基化/羟甲基化关系及研究进展

Association Between Coronary Heart Disease with Blood Stasis Syndrome and DNA Methylation/Hydroxymethylation and Related Research Advances

冠心病是由遗传因素和环境因素相互作用而引起的多基因异常的复杂性状疾病,血瘀证是其常见证型之一。随着冠心病表观遗传学的研究发展,DNA甲基化和去甲基化作为表观遗传中重要的修饰形式之一,二者参与了多种疾病的病理生理改变,已有研究表明表观遗传学中DNA甲基化修饰与癌症、动脉粥样硬化疾病的发生发展密切相关。而DNA羟甲基化修饰作为DNA去甲基化修饰的关键中间环节也同时参与了基因的表达调控,与癌症和精神性疾病的发生有紧密联系。本团队前期研究表明:DNA甲基化修饰是冠心病血瘀证的发病机制之一,基于DNA甲基化与羟甲基化之间相互转化的关系,本文推测DNA羟甲基化修饰也与心血管疾病密切相关;冠心病血瘀证的发生和发展可能与5-甲基胞嘧啶和5-羟甲基胞嘧啶之间的转化有紧密联系。

Coronary heart disease （CHD） is a complex disease with polygenie abnormalities caused by the interaction between genetic and environmental factors, and blood stasis syndrome is one of the most common syndromes of CHD. With the development of epigeneties of CHD, DNA methylation and demethylation are one of the imporlant forms of modification in epigeneties and are involved in the pathophysiologieal changes of many diseases. Some studies have shown that DNA methylation in epigeneties is closely associated with the development and progression of cancer and atheroselerosis. As a key intemlediate link of DNA demethylation, DNA hydroxymethylation is also involved in gene expression regulation and is closely associated with the development of cancer and mental diseases. The previous studies of our team have shown that DNA methylation is one of the pathogeneses of CHD with blood stasis syndrome. Based on the mutual transformtion between DNA methylation and hydroxymethylation, DNA hydroxymethylation may also be closely associated with cardiovascular diseases; the development and progression of CHD with blood stasis syndrome may be closely associated with the transformtion between 5-methyleytosine and 5-hydroxymethyleytosine.