前列腺癌人工去势与内分泌治疗所致贫血的对比分析

Comparative analysis of anemia caused by artificial castration and endocrine therapy in prostate cancer

目的对比分析前列腺癌人工去势与内分泌治疗所致贫血现象。方法按随机数字表法将2017年1~12月我院接诊的男性前列腺癌70例分为两组。对照组35例患者接受内分泌治疗,研究组35例患者给予人工去势治疗(即双侧睾丸切除术)。比较两组治疗后第1、2、3个月时性激素水平[血清总睾酮(TT)、前列腺特异性抗原(PSA)、游离睾酮(FT)]和各项血常规指标[红细胞计数(RBC)、血红蛋白(Hb)、血细胞比容(HCT)、平均红细胞体积(MCV)],并记录两组贫血发生情况。结果治疗后第1个月对照组PSA水平低于研究组,差异具有统计学意义(P <0.05),两组TT、FT水平比较,差异无统计学意义(P> 0.05),治疗后第2、3个月对照组TT、FT、PSA水平均低于研究组,差异具有统计学意义(P <0.05);两组治疗后第1、2、3个月时HCT水平比较,差异无统计学意义(P> 0.05),治疗后第1个月时两组Hb、RBC水平比较,差异无统计学意义(P> 0.05),治疗后第2、3个月研究组Hb、RBC水平明显高于对照组,差异具有统计学意义(P<0.05);研究组贫血发生率为80.00%(28/35)低于对照组的91.43%(32/35),组间比较差异无统计学意义(P> 0.05)。结论前列腺癌人工去势与内分泌治疗均能有效降低雄激素水平,但与人工去势相比,内分泌治疗降低雄激素效果更为明显,但其贫血发生率更高。

Objective To compare and analyze the anemia caused by artificial castration and endocrine therapy in prostate cancer. Methods According to the random number table method, 70 male patients with prostate cancer admitted to our hospital from January 2017 to December 2017 were divided into two groups. In the control group, 35 patients received endocrine therapy, and in the study group, 35 patients received artificial eastration（ie, bilateral orchiectomy）. The levels of sex hormones including total testosterone（TT）, prostate specific antigen（PSA）, free testosterone（FT）, and blood routine indicators including red blood eells（RBC）, hemoglobin（Hb）, hematoerit（HCT）, mean corpuscular volume（MCV） were compared at the 1st, 2nd and 3rd months after treatment in both groups, and the anemia in the two groups were recorded. Results The PSA level in the control group was lower than that in the study group at the first month after treatment（P 〈 0.05）. There was no significant difference in TT and FT levels between the two groups（P 〉 0.05）. The levels of TT, FT and PSA in the control group at second, third months after treatment were lower than those in the study group（P 〈 0.05）. There was no significant difference in HCT level at first, second, third months after treatment（P 〉 0.05）. There was no significant difference in the levels of Hb and RBC between the two groups a! first months after treatment（P 〉 0.05）. The levels of Hb and tlBC in the study group were significantly higher than those in the control group a! the second and third months after treatment, the difference was statistically signifieant（P 〈 0.05）. The incidence of anemia in the study group was 80.00%（28/35） and lower than that of the control group which was 91.43%（32/35）, and there was no significant difference between the groups（P 〉 0.05）. Conclusion Both artificial castration and endocrine therapy of prostate cancer can effectively reduce the level of androgen, but compared with artificial castration, endocrine therapy is more effective in reducing androgen, but the incidence of anemia is higher.