啤酒抗冷混浊硅基吸附剂对SD大鼠的胚胎毒性和致畸毒性

Teratogenic investigation of a silicon adsorbent for cold turbidity of beer on SD rats

目的:检测啤酒抗冷混浊硅基吸附剂对大鼠的胚胎毒性及致畸毒性。方法:按0.83、1.67、3.33g/kg灌胃给予孕期第7～16天的SD大鼠啤酒抗冷混浊硅基吸附剂水溶液,每天1次,连续给予10d后检查受试物对孕鼠体质量,胚胎发育,胎仔身长、尾长、外观畸形、内脏畸形和骨骼畸形的影响。同时设阴性对照组(蒸馏水)。结果:与阴性对照组比较,啤酒抗冷混浊硅基吸附剂各剂量组孕鼠及胎鼠的各项观察指标的差异均无统计学意义(P均>0.05)。结论:啤酒抗冷混浊硅基吸附剂对SD大鼠无胚胎毒性和致畸毒性。

OBJECTIVE： To investigate embryo toxicity and teratogenicity of a silicone adsorbent for cold turbidity of beer on rats. METHODS ： SD rats during pregnancy were given intragastric administration of silicon-based sorbent at 0.83, 1.67 and 3.33 g/kg, respectively. After continuous administration of 10 d, growth of pregnant rats, embryonic development, fetal appearance, visceral deformities, and skeletal deformities were monitored. RESULTS： There was no significant difference in the observation indexes between pregnant rats and fetal rats in each dose group and the negative control group （all P〉0.05）. CONCLUSION： The silicon sorbent did not show reproductive toxicity nor teratogenic effects in SD rats.