亚甲蓝对脑缺血再灌注损伤保护机制的研究进展

Research progress on the protective mechanism of methylene blue against cerebral ischemia and reperfusion injury

大脑是人体各器官中对缺血、缺氧最为敏感的器官。各种原因引起的脑部缺血，可造成脑部的缺血性损伤，但在随后的治疗中恢复再灌注后又会引起活性氧的大量产生，通过各种分子机制最终导致神经元细胞的坏死或凋亡引发再灌注损伤。亚甲蓝（MB）作为一种神经系统疾病研究热点药物，具有抗氧化性，可迅速穿过血脑屏障，对脑部神经元细胞有一定保护作用。本文将对脑缺血／再灌注（I／R）损伤机制及亚甲蓝对脑缺血／再灌注损伤的保护机制进行综述。

Brain is the most sensitive organ to ischemia and hypoxia of human body. Various causes of cerebral ischemia, can cause isehemic injury to the brain, but in the subsequent treatment of reperfusion after reperfusion will cause a large number of reactive oxygen species produced through a variety of molecular mechanisms ultimately lead to neuronal cells necrosis or apoptosis initiating reperfusion injury. Methylene blue is a hotspot drug for the study of nervous system diseases. It has antioxidant properties and can quickly cross the blood -brain barrier and has a protective effect on neurons in the brain. This article reviews the mechanism of cerebral ischemia - reperfusion injury and the protective mechanism of methylene blue on cerebral ischemia - reperfusion injury.