肝硬化腹水1号汤联合腹水超滤量回输法对难治性肝硬化腹水伴Ⅱ型肝肾综合征的影响

Effect of No.1 Decotion of Liver Cirrhosis Ascites Combined with Ascites Reinfusion Method for Refractory Ascites Due to Cirrhosis with Type Ⅱ Hepatorenal Syndrome

目的:观察肝硬化腹水1号汤联合腹水超滤量回输法对难治性肝硬化伴Ⅱ型肝肾综合征的治疗效果。方法:选取2015年3月~2017年3月在本院收治的确诊为肝硬化失代偿期并难治性肝腹水伴Ⅱ型肝肾综合征患者90例,按照数字表法将其随机分为观察组和对照组各45例。对照组给予腹水超滤浓缩腹腔回输治疗,观察组在此基础上给予肝硬化腹水1号汤加减口服。观察两组患者腰围、体重、尿量、血肌酐、血钾、血尿素氮等情况,并分析两组不良反应发生及腹水复发情况。结果:两组患者治疗后腰围、体重、尿量、血肌酐、血钾、血尿素氮等情况均有明显改善,组内比较,P<0.05;治疗后观察组各项指标比对照组改善更明显,P<0.05;观察组不良反应发生率(17.78%)与对照组(22.2%)比较,差异不显著(P>0.05);观察组腹水复发率为33.3%,明显低于对照组(62.5%),P<0.05。结论:对于难治性肝硬化腹水伴Ⅱ型肝肾综合征患者,给予中药肝硬化腹水1号汤联合腹水超滤量回输法治疗,能明显改善患者肝肾综合征相关指标和症状,降低腹水复发率,有较高的安全性。

Objective：To investigate the therapeutic effect of No.1 Decoctioin of Liver Cirrhosis Ascites combined with ascites ultrafiltration reinfusion method for type II hepatorenal syndrome of refractory cirrhosis.Methods：Selected from March 2015 to March 2017 in our hospital were diagnosed with decompensated liver cirrhosis and refractory ascites with type II hepatorenal syndrome in 90 cases,according to the digital table method,the patients were randomly divided into observation group and controlled group with 45 cases in each group.The controlled group was treated with ultrafiltration and reinfusion of ascites,on this basis,the observation group was given No.1 Decoction of Liver Cirrhosis Ascites.Waist circumference,body weight,urine output,serum creatinine,serum potassium and blood urea nitrogen were observed in the two groups,the incidence of adverse reactions and recurrence of the two groups were analyzed.Results：After treatment,waist circumference,body weight,urine volume,serum creatinine,serum potassium and blood urea nitrogen were significantly improved in the two groups,in group comparison,P〈0.05;After treatment,the observation group was better than the controlled group,P〈0.05;The incidence of adverse reactions in the observation group（17.78%） was compared with the controlled group（22.2%）,no significant difference（P〉0.05）;The recurrence rate of the observation group was 33.3%,which was significantly lower than that of the controlled group（62.5%）,P〈0.05.Conclusion：For refractory ascites due to cirrhosis with hepatorenal syndrome in patients with type II,it is given to the treatment of No.1 Decoction of Liver Cirrhosis Ascites and ascites ultrafiltration,can significantly improve the symptoms and signs of hepatorenal syndrome,reduce the recurrence rate of ascites,it has high security.