囊泡单胺转运蛋白2基因多态性与帕金森病患者抑郁状态相关性的研究

Association between vesicular monoamine transporter 2 polymorphisms and depression in Parkinson's disease

目的研究囊泡单胺转运蛋白2(VMAT2)的rs363371和rs363324基因多态性与汉族人群中PD患者合并抑郁状态的相关性。方法收集102例汉族帕金森病(PD)患者,通过采用17项汉密尔顿抑郁量表(HAMD-17)将患者分为PD合并抑郁组和PD未合并抑郁组,用连接酶法对VMAT2的rs363371和rs363324进行了基因型分型,运用二元Logistic回归检验分析PD患者合并抑郁的危险因素。结果 rs363371的AA基因型降低了PD患者合并抑郁的风险(OR=0.22,59%CI 0.07-0.75,P=0.015)。UP3的高分值增加了PD患者合并抑郁的风险(OR=1.08,59%CI 1.02-1.15,P=0.009)。较长的病程增加了PD患者合并抑郁的风险(OR=1.15,59%CI 1.01-1.31,P=0.038)。rs363324的基因多态性并未增加PD合并抑郁的风险。结论 VMAT2的rs363371的AA基因型降低了汉族人群PD患者合并抑郁的风险。

Objective To investigate the association between vesicular monoamine transporter 2 （VMAT2） polymorphisms, rs363371 and rs363324, and depression in the Han Chinese population with Parkinsons disease （PD）. Methods A total of 102 Han Chinese patients with PD were enrolled and divided into PD with depression group and PD without depression group according to the 17-item Hamilton Depression Rating Scale. The two single nucleotide polymorphisms （SNPs） of VMAT2, rs363371 and rs363324, were genotyped using ligase detection reaction. Binary logistic regression was used to analyze the risk factors for depression in PD. Results The AA genotype at rs363371 reduced the risk of depression in PD [ odds ratio （OR） = 0.22, 95% confidence interval （CI） ： 0.07-0.75, P = 0.015 ]. The high score for UP3 increased the risk of depression in PD （ OR = 1.08, 95% CI： 1.02-1.15, P = 0.009）. Long duration of PD increased the risk of depression in PD （ OR = 1.15, 95% CI： 1.01-1.31, P = 0.038）. The VMAT2 SNP rs363324 did not increase the risk of depression in PD. Conclusions The AA genotype at rs363371 reduces the risk of depression in the Han Chinese population with PD.