细胞命运决定子Numb调控肝癌发生的研究进展

Advances in research on cell fate determinant Numb regulating liver cancer

肝癌是我国最常见的恶性肿瘤之一，位居恶性肿瘤的第5位；死亡人数位居肿瘤相关死亡的第3位。细胞命运决定子Numb作为一种膜相关蛋白，其不对称分布对细胞分化起着关键作用。研究报道Numb与肿瘤的发生发展关系密切，近几年其在肝癌中的重要作用也逐渐被学者重视。现就Numb分子的结构、Numb与肿瘤发生，Numb调控的肿瘤的分子机制，以及Numb在肝癌发生发展中的作用等方面做一简要综述。

Liver cancer is one of the most common malignant tumors in China, ranking fifth in malignant tumors and the third in tumor-related deaths. As a membrane-related protein, the asymmetric distribution of cell fate determinant Numb plays a key role in cell differentiation. Research reports that Numb may be closely associated to the occurrence and development of tumors. Recently, scholars have gradually valued its important role in liver cancer. This article briefly reviews the structure of Numb molecule, relationship between Numb and tumorigenesis, the molecular mechanism of Numb-regulated tumors, and the role of Numb in the development of liver cancer.