肝硬化患者血清PCT及炎症指标检测意义

Significance of measuring serum PCT and inflammatory markers in patients with cirrhosis

目的检测肝硬化患者血清PCT及炎症指标,指导临床疾病诊断和治疗。方法收集60例肝硬化患者的临床资料,检测患者PCT、hs-CRP、WBC、中性粒细胞百分比(N%)水平,并对结果进行统计学分析。结果 60例肝硬化患者感染率为45.00%,男、女性感染率分别为44.74%和45.45%,差异无统计学意义(χ2=0.002 9;P=0.957 1);主要感染部位在下呼吸道、腹腔、肠道、尿道、胆道及其他部位的患者分别占33.33%、25.93%、18.52%、11.11%、7.41%、3.70%;下呼吸道部位感染与其他部位相比,差异有统计学意义(χ2=6.000 0,P=0.014 3)。肝功能Child分级B级和C级患者感染率分别为26.32%和53.66%,差异有统计学意义(χ2=3.921 9,P=0.047 7)。由乙型肝炎和丙型肝炎引发肝硬化的患者感染率分别为11.11%和72.73%,差异有统计学意义(χ2=22.779 3,P=0.0000)。肝硬化感染患者PCT水平为(2.94±1.57)ng/ml,未感染患者为(0.16±0.10)ng/ml,差异有统计学意义(t=9.016,P=0.000);肝硬化感染患者hs-CRP水平为(24.68±15.57)mg/L,未感染患者为(11.93±8.25)mg/L,差异有统计学意义(t=3.418,P=0.002);肝硬化感染患者WBC水平为(8.14±3.05)×109/L,未感染患者为(3.79±1.73)×109/L,差异有统计学意义(t=6.024,P=0.000);肝硬化感染患者N%水平为(84.86±8.72)%,未感染患者平为(56.68±8.87)%,差异有统计学意义(t=10.067,P=0.000);结论肝硬化患者血清PCT、hs-CRP、WBC及N%水平检测对患者发病的诊断和治疗具有指导意义。

Objective To measure serum PCT and inflammatory indices in patients with cirrhosis in order to guide the diagnosis and treatment of disease in clinical settings. Methods Clinical data on 60 patients with cirrhosis were collected to measure PCT,hs-CRP,the WBC count,and the N%in patients,and the results were statistically analyzed. Results The rate of infection was 45.00%in 60 patients with cirrhosis.The rate of infection for male patients was 44.74%and that for female patients was 45.45%.The rate of infection did not differ significantly by sex（χ2=0.0029,P=0.9571）.The main site of infection was the lower respiratory tract in 33.33% of patients,the abdominal cavity in 25.93%,the intestinal tract in 18.52%,the urethra in 11.11%,the biliary tract in 7.41%,and some other site in 3.70%.The lower respiratory tract was significantly more often the site of infection than other sites（χ2=6.000 0,P=0.014 3）.The rate of infection was 26.32%in patients with class B liver function and 53.66%in those with class C liver function.The rate of infection differed significantly in the 2 groups（χ2=3.9219,P=0.0477）.In 11.11% of patients,cirrhosis was due to infection with hepatitis B,and in 72.73% of patients cirrhosis was due to infection with hepatitis C.The rate of infection differed significantly in the 2 groups（χ2=22.779 3,P=0.0000）.The level of PCT was 2.94±1.57 ng/ml in patients with cirrhosis and an infection and 0.16±0.10 ng/ml in patients with cirrhosis and no infection.The level of PCT differed significantly in the 2 groups（t=9.016,P=0.000）.The level of hs-CRP was 24.68±15.57 mg/L in patients with cirrhosis and an infection and 11.93±8.25 mg/L in patients with cirrhosis and no infection.The level of hs-CRP differed significantly in the 2 groups（t=3.418,P=0.002）.The WBC count was 8.14±3.05×109/L in patients with cirrhosis and an infection and 3.79±1.73×109/L in patients with cirrhosis and no infection.The WBC count differed significantly in the 2 groups（t=6.024,P=0.000）.The N% was 84.86±8.72%in patients with cirrhosis and an infection and 56.68±8.87%in patients with cirrhosis and no infection.The N% differed significantly in the 2 groups（t=10.067,P=0.000）. Conclusion In patients with cirrhosis,serum PCT,hs-CRP,the WBC count,and the N%are significant indices that can guide the diagnosis and treatment of disease.