期刊文献+

瑞舒伐他汀在冠心病合并高脂血症治疗中的应用及对血清hs-CRP、MFG-E8和Klotho的影响 被引量:3

下载PDF
导出
摘要 目的探讨瑞舒伐他汀在冠心病合并高脂血症治疗中的应用及对血清hs-CRP(超敏C反应蛋白)、MFG-E8(乳脂肪球表皮生长因子)和Klotho的影响。方法选取我院70例冠心病合并高脂血症患者,随机将其分为两组,两组患者入院后均给予常规治疗,在这一治疗基础上,研究组给予瑞舒伐他汀进行治疗,对比两组临床疗效和血清hs-CRP、MFG-E8、Klotho变化情况。结果对照组高脂血症治疗总有效率和血脂达标率分别为71.43%和60.00%,研究组为94.29%和88.57%,组间差异显著(P<0.05);经治疗结束后,两组患者血清hs-CRP、MFG-E8和Klotho水平均明显改善,且相较于对照组,研究组改善程度更大,组间差异显著(P<0.05)。结论瑞舒伐他汀治疗冠心病合并高脂血症具有显著疗效,且有助于改善血清hs-CRP、MFG-E8、Klotho水平。
作者 潘志东
机构地区 河池市中医医院
出处 《心血管病防治知识(学术版)》 2018年第8期23-24,共2页 Prevention and Treatment of Cardiovascular Disease
  • 相关文献

参考文献5

二级参考文献44

  • 1Rajesh Kumar G,Mrudula Spurthi K,Kishore Kumar G,et al.Correction:evaluation of hs-CRP levels and interleukin 18(-137G/C)promoter polymorphism in risk prediction of coronary artery disease in first degree relatives[J].PLo S One,2015;10(5):e0127609.
  • 2中华人民共和国卫生部.冠状动脉粥样硬化性心脏病诊断标准[S].中华人民共和国卫生行业标准WS319—2010.
  • 3Patel S, Celermajer DS, Bao S. Atherosclerosis-underlying inflammatory mechanisms and clinical implications[J]. Int J Biochem Cell Biol,2008,40(4) :576-580.
  • 4Roth EM, Mckenney JM, Kelly MT, et al. Efficacy and safety of rosuvastatin and fenofibric acid combination therapy versus simvastatin monotherapy in patients with hypercholesterolemia and hypertriglyceridemia[J]. Am J Card Drug,2010,10(3) :175-186.
  • 5Dai W,Li Y,Lv YN,et al. The roles of a novel anti-in- flammatory factor,milk fat globule-epidermal growth fac- tor 8,in patients with coronary atherosclerotic heart dis- ease[J]. Atherosclerosis,2014,233(2): 661-665.
  • 6Ridker PM, Macfadyen JG, Fonseca FA, et al. Number needed to treat with rosuvastatin to prevent first cardio- vascular events and death among men and women with low low-density iipoprotein cholesterol and elevated high- sensitivity C-reactive protein:justification for the use of statins in prevention: an intervention trial evaluating ro- suvastatin (Jupiter)[J]. Circ Cardiovasc Quai Outcomes, 2009,2(6) :616-623.
  • 7Brown TM, Bittner V. Management of stable patients with coronary heart disease: Clinical implications of the Clinical Outcomes Utilizing Revascularization and Ag- gressive Drug Evaluation (COURAGE) trial[J]. J Clin Lipidol, 2007,1(6): 564-574.
  • 8Anderson JL, Adams CD, Antman EM, et al. 2011 ACCF/ AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with un- stable angina/Non-ST-Elevation myocardial infarction: a report of the American college of cardiology foundation/ American heart association Tas[J]. Circulation, 2011,123 (18) : e426-e579.
  • 9Montero-Vega MT. The inflammatory process underlying atherosclerosis[J]. Crit Rev Immunol, 2012,32 (5): 373- 462.
  • 10Manduteanu I,Simionescu M. Inflammation in atheroscle- rosis..a Cause or a result of vascular disorders? [J]. J Cell Mol Med,2012,16(9):1978-1990.

共引文献119

同被引文献24

引证文献3

二级引证文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部