奥曲肽治疗肠梗阻的有效性及安全性评价

Evaluation of the efficacy and safety of octreotide in the treatment of intestinal obstruction

目的研究探讨奥曲肽治疗肠梗阻的有效性及安全性。方法选择2016年7月~2017年12月本院60例肠梗阻患者作为研究对象,所有患者随机分为对照组与观察组,每组30例。对照组采用常规入院治疗,观察组在对照组基础上加用奥曲肽进行治疗,观察比较两组患者的治疗效果、不良反应发生情况以及腹痛腹胀缓解时间、住院时间、肛门排气时间。结果观察组患者治疗后总有效率为90.0%,对照组治疗后总有效率为73.3%,两组比较差异有统计学意义(P<0.05)。观察组不良反应发生率为6.7%,对照组为16.7%,两组比较差异有统计学意义(P<0.05)。观察组腹痛腹胀缓解时间、住院时间、肛门排气时间明显短于对照组,差异有统计学意义(P<0.05)。结论对于肠梗阻的患者,采取常规方法加用奥曲肽进行治疗,可以提高治疗的效果,减少患者出现不良反应的情况,值得在今后患者的治疗过程中应用。

Objective To study the efficacy and safety of octreotide in the treatment of intestinal obstruction. Methods 60 patients with intestinal obstruction from July 2016 to December 2017 were randomly divided into control group and observation group with 30 cases in each group. The patients in the control group were treated with octreotide on the basis of routine admission, and the patients in the two groups were treated with octreotide.The therapeutic effects, adverse reactions, abdominal pain and abdominal distension relief time, hospitalization time and anal exhaust time were observed and compared between the two groups. Results The total effective rate after treatment was 90.0%in the observation group and 73%in the control group.The difference between the two groups was statistically significant （P〈0.05）. The incidence of adverse reactions in the observation group was 6.7% and that in the control group was 16.7%.The difference between the two groups was statistically significant （P〈0.05）. The time of abdominal distension relief, hospitalization and anal exhaust in the observation group were significantly shorter than those in the control group （P〈0.05）. Conclusion For the patients with intestinal obstruction, routine treatment with octreotide can improve the effect of treatment and reducethe adverse reactions of patients. It is worthy to be used in the treatment of patients in the future.