肺结核早期诊断中不同检验方法的应用分析

Application and analysis of different test methods in early diagnosis of pulmonary tuberculosis

目的探讨肺结核早期诊断中不同检验方法的临床应用价值。方法对我院2016年4月~2017年9月收治的肺结核早期患者51例为观察组,同时选取51例非肺结核患者作为对照组,分别对两组患者实施涂片结核菌检测、皮肤结核菌素纯蛋白衍化物(PPD)及聚合酶链反应(PCR)等3种检验方法,对比分析3种检验方法在肺结核早期诊断中的临床应用价值。结果3种检验方法中,观察组的阳性率均显著高于对照组,差异均有统计学意义(P<0.05)。PCR检测结核菌阳性率为72.55%,显著高于涂片结核菌检测、PPD检测的50.98%、21.57%,差异均有统计学意义(P<0.05)。结论肺结核早期诊断中,3种检验方法临床效果均显著,相比于涂片结核菌检测及PPD检验、PCR检验灵敏度更高,值得临床推广使用。

Objective To explore the clinical application value of different test methods in early diagnosis of pulmonary tuberculosis. Methods A total of 51 patients with early pulmonary tuberculosis admitted in our hospital from April 2016 to September 2017 were selected as the observation group,and another 51 cases of non tuberculosis patients were selected as the control group.2 groups of patients were examined by smear,tuberculous bacteria test,skin tuberculin pure protein derivative （PPD） and polymerase chain reaction （PCR） and other 3 test methods.The clinical value of 3 test methods in the early diagnosis of pulmonary tuberculosis was comparatively analyzed. Results Among the 3 methods,the positive rate of the observation group was significantly greater than that of the control group,and the comparison was statistically significant （ P 〈0.05）.The positive rate of Mycobacterium tuberculosis detected by PCR was 72.55%,which was significantly higher than that of smear tuberculin detection,50.98% and 21.57% of PPD detection,and the comparison was statistically significant （ P 〈0.05）. Conclusion In the early diagnosis of pulmonary tuberculosis,the 3 methods have significant clinical effects.Compared with smear,TB detection and PPD detection,PCR detection has higher sensitivity and is worthy of clinical promotion.