艾司西酞普兰联合米氮平治疗老年抑郁症伴失眠的临床疗效观察

Investigation of Clinical Curative Effect of Escitalopram Combined with Mirtazapine for the Treatment of Elderly Depression with Insomnia

目的:观察艾司西酞普兰联合米氮平治疗老年抑郁症伴失眠的临床疗效。方法:研究采取随机对照研究,选取2017年5月至2018年3月临沂市精神卫生中心收治的符合研究标准者60例,随机分为观察组(艾司西酞普兰联合米氮平)与对照组(艾司西酞普兰),每组30例,治疗时间8周。结果:观察组、对照组4周、8周PSQI评分、HAMD评分较治疗前均有显著下降(P<0.01),而观察组各时点评分均显著低于对照组(P<0.01)。2组有效率比较显示观察组有效率显著优于对照组(P<0.05)。结论:艾司西酞普兰联合米氮平能够更好的改善老年抑郁症患者失眠症状,改善患者抑郁状态,且无更多不良表现出现。研究在一定程度上证实艾司西酞普兰联合米氮平更适合老年抑郁症失眠为主表现者。

Objective： To observe that the clinical efficacy of escitalopram combined with mirtazapine in the treatment of elderly depression with insomnia. Methods： Our studies using randomized controlled studies,selected 60 subjects who met the research criteria.It was randomly divide into groups of treatment （escitalopram combined with mirtazapine） and control group （escitalopram）,30 cases in each group and 8 weeks of treatment. Results： The PSQI score and HAMD score of the treatment group and the control group at 4 weeks and 8 weeks were significantly lower than those before treatment （ P 〈0.01）,while the scores of each time point in the treatment group were significantly lower than those of the control group （ P 〈0.01）.The comparison between the two groups showed that the efficiency of the treatment group was significantly better than that of the control group （ P 〈0.05）. Conclusion： Escitalopram combined with mirtazapine can better improve the insomnia symptoms of elderly patients with depression,improve the depression status of patients,and no more adverse manifestations.To some extent,the study confirmed that escitalopram combined with mirtazapine was more suitable for the elderly depression patients whose insomnia are more prominent.