摘要
ObjectiveTo 在 time.MethodsThe 上与 atrial 纤维性颤动(AF ) 在病人为节奏控制与 antiarrhythmic 药治疗(ADT ) 相比在导管脱离的功效和安全评估变化的趋势联机数据库 PubMed 和 EMBASE 被在找相关研究。STATA 软件(版本 12.0 ) 被用来执行元分析和 meta-regression.ResultsFifteen 包括有 AF 的 2249 个病人的使随机化的控制试用被识别。分享的结果证明那导管脱离与 ADT 相比在 AF 复发的风险与 52% 减小被联系[风险比率(RR )= 0.48， 95% 信心间隔(CI ) ：0.40-0.57，我 <sup>2</sup>=70.7%) 。亚群分析证明那导管脱离在 2011 前与研究相比在 2011 以后在研究展出了更少的功效(RR = 0.61， 95% CI：0.54-0.68，我 <sup>2</sup>=9.3% 并且 RR = 0.34， 95% CI：0.24-0.47，我 <sup>2</sup>=69.9% ，分别地) ，并且安全结果更高显示出 1.08 褶层不利事件的发生(14.2% 对 7.3% ；RR = 1.08， 95% CI：1.04-1.13 ) 在在 2011 .ConclusionsCatheter 以后的研究，脱离看起来比为节奏控制的 ADT 优异。然而，更少的功效和不利事件的更高的率在 2011 前与研究相比在 2011 以后在研究被观察。
Objective To evaluate the trend of change in the efficacy and safety of catheter ablation compared with antiarrhythmic drug therapy （ADT） for rhythm control in patients with atrial fibrillation （AF） over time. Methods The online databases PubMed and EMBASE were searched for relevant studies. STATA software （version 12.0） was used to perform the meta-analysis and meta-regression. Results Fifteen randomized controlled trials including 2249 patients with AF were identified. The pooled results showed that catheter ablation was associated with a 52% reduction in the risk of AF recurrence compared with ADT [risk ratio （RR） = 0.48, 95% confidence interval （CI）： 0.40-0.57, I2 = 70.7%）. Subgroup analyses showed that catheter ablation exhibited less efficacy in studies after 2011 compared to studies before 2011 （RR = 0.61, 95% CI： 0.54-0.68, I2 = 9.3% and RR = 0.34, 95% CI： 0.24-0.47, I2 = 69.9%, respectively）, and the safety outcome showed a 1.08-fold higher incidence of adverse events （14.2% vs. 7.3%; RR = 1.08, 95% CI： 1.04-1.13） in studies after 2011. Conclusions Catheter ablation appears to be superior to ADT for rhythm control. However, less efficacy and a higher rate of adverse events were observed in studies after 2011 compared to studies before 2011.
