地佐辛与曲马多用于骨科术后自控镇痛临床效果的比较

Comparison the clinical effect of Dezocine and Tramadol used in postoperative patient-controlled analgesia in department of orthopedics

目的比较地佐辛与曲马多用于骨科术后患者自控镇痛(PCA)的效果。方法选择2017年1~5月在本院行全麻下下肢长骨骨折手术患者100例,按照随机数字表法分为地佐辛组(D组)50例,曲马多组(Q组)50例。D组术后采用地佐辛+舒芬太尼镇痛,Q组术后采用曲马多+舒芬太尼镇痛。比较两组患者在不同时间点疼痛视觉模拟量表(VAS)评分,自控镇痛(PCA)按压次数以及PCA药物用量,镇静评分,不良反应发生率以及满意度。结果两组患者术后静止和运动状态下各时间点的VAS评分、术后不同时间点的PCA按压次数、PCA药物用量,镇静评分、满意度评分比较,差异均无统计学意义(P>0.05);D组患者术后恶心呕吐(PONV)发生率低于Q组,差异有统计学意义(P<0.05)。结论地佐辛与曲马多用于骨科术后的PCA效果相似,但其PONV发生率较低。

Objective To compare the effect of Dezocine and Tramadol used in postoperative patient-controlled analgesia in department of orthopedics. Methods A total of 100 patients with lower extremity long bone fracture underwent general anesthesia in our hospital from January to May 2017 were selected, and they were divided into the group D（50 cases）and group Q（50 cases） according to the random number table method. Group D was treated with Dezocine plusing Sufentanil for analgesia, while the group Q was treated with Tramadol and Sufentanil after operation. Pain visual analogue scale（VAS）, PCA compression times, PCA dosage of drugs at different time points, sedation score, incidence of adverse reactions and satisfaction degree were compared between the two groups. Results There were no significant differences in VAS score at different time points in the state of rest and movement after operation, PCA compression times and PCA dosage of drugs at different time points after operation, sedation score and satisfaction score between the two groups（P〉0.05）. The incidence of postoperative nausea and vomiting（PONV） in the group D was lower than that in group Q, and the difference was statistically significant（P〈0.05）. Conclusion Dezocine and Tramadol have similar PCA effect on after orthopaedic surgery, but the incidence of PONV is lower.