淮安市艾滋病抗病毒治疗依从性影响因素研究

Analysis of influential factors on compliance of antiretroviral therapy among AIDS patients in Huaian city

目的评估疾控管理模式下艾滋病抗病毒治疗患者的服药依从性,并探索其影响因素。方法对2015年3月31日前开始艾滋病抗病毒治疗且仍然在治273例患者开展问卷调查,利用药片计数法和自我报告法,综合判定患者服药依从性并对影响因素进行分析。结果服药依从性好者242例,占88.64%。多因素logistic回归分析显示,初中文化、治疗方案中含依非韦伦、固定服药时间、服药未超固定服药时间2小时以上患者的服药依从性较好(P<0.05)。结论淮安市艾滋病抗病毒治疗患者的服药依从性较高,主要受文化程度、药物及服药认知的影响。

Objective To assess the compliance of antiretroviral therapy and its influential factors among AIDS patients managed by Disease Control and Prevention. Methods A questionnaire based survey was carried out among 273 patients initially received ART before Mar 31 st , 2015 and now still in treatment. The compliance to ART was determined by both pill counting method and self-reporting method, the related influential factors were analyzed. Results Of all patients who completed the study,242 patients reported full compliance ,accounted for 88.64%. Multivariate logistic regression analysis showed that patients with junior high school education, taking Efavirenz Tablets ,with fixed time of medication,or taking the medicine without more than 2 hours later than the fixed time were associated with good compliance（all P 〈0.05）. Conclusion The compliance to ART among AIDS patients in Huaian was relatively high, which was mainly affected by degree of education, drugs and drug perception.