丘脑底核深部电刺激对不同性别帕金森病病人生活质量的影响

Effects of subthalamic nucleus deep brain stimulation on quality of life of Parkinson′s patients in different genders

[目的]探讨丘脑底核深部电刺激治疗(STN DBS)对不同性别帕金森病病人生活质量的影响。[方法]术前和术后6个月随访时用帕金森病人生活质量问卷(PDQ-39)和统一帕金森病评定量表(UPDRS)评估病人的生活质量和病情严重程度,比较手术前后和不同性别病人得分。[结果]术前,不同性别病人病程和运动功能(UPDRSⅢ)得分差异均无统计学意义;术后,病人运动功能提高且性别间差异无统计学意义;PDQ-39得分显示,仅有女性病人身体活动、病耻感、认知和总得分降低,仅有男性病人身体不适得分降低。[结论]尽管STN DBS对改善病人运动功能方面不存在性别差异,但术后女性病人的生活质量较男性得到更大程度提升。

Objectives： To explore the effect of subthalamic nucleus deep brain stimulation （STN DBS） on quality of life between men and women patients with Parkinson′s disease （PD）. Methods： The quality of life and disease severity of patients with PD were assessed by quality of life questionnaire （PDQ 39） and the unified Parkinson′s Disease Rating Scale （UPDRS） before survey and at postoperative 6 months. Results： There was no statistically significant difference in the score of disease and motor function（UPDRS Ⅲ） between different genders of patients before operation.The motor function was improved and there was no statistically significant difference between different genders after operation.The PDQ 39 score showed that,just women showed a decrease in mobility,stigma cognition and the total score, while only man had a decrease in discomfort score. Conclusion： Although STN DBS had no gender differences in improving motor function of patients,quality of life was improved in a greater extent in women patients than that of men.