FOXA1、p16在子宫内膜癌中的表达情况及其临床意义

The expression of FOXA1 and p16 in endometrial carcinoma and its clinical significance

目的:探讨FOXA1、p16在子宫内膜癌组织中的表达情况及其临床意义。方法:采用免疫组化方法检测FOXA1、p16在68例子宫内膜癌组织、11例不典型增生组织及27例正常子宫内膜组织中的表达情况,分析2者与子宫内膜癌各临床病理指标的相关性以及2者表达的相关性。结果:子宫内膜癌组织中FOXA1、p16阳性表达率均低于正常子宫内膜组织及不典型增生内膜组织,差异具有统计学意义(P<0.05);FOXA1、p16的表达与子宫内膜癌病理分期、组织分级、肌层浸润、病理类型及淋巴结转移情况有关(P<0.05);2者在子宫内膜癌中的表达呈正相关。结论:FOXA1和p16与子宫内膜癌的发生发展相关,2者在子宫内膜癌的发展中具有协同作用。

Objective： To investigate the expression of FOXA1 and p16 in endometrial carcinoma and its clinical significance. Methods： Immunohistochemistry was used to detect the expression of FOXA1 and p16 in 68 cases of endometrial carcinoma,11 cases of atypical hyperplasia and 27 cases of normal endometrium. Analysis of the correlation between the expression of the two indexes and the clinicopathological parameters was conducted.Results： The positive expression level of FOXA1 and p16 in the endometrial cancer tissues was lower than that in normal endometrium and atypical hyperplasia of endometrium,with statistically significant difference （P〈 0. 05）.The expression of FOXA1 and p16 was correlated with the endometrial carcinoma pathological stage,histological grade,myometrial invasion,pathological type and lymph node metastasis （P〈 0. 05）. The expression of FOXA1 and p16 was positively related in endometrial carcinoma. Conclusions： FOXA1 and p16 are associated with the development of endometrial carcinoma,and are synergistic in the development of endometrial carcinoma.