合并梅毒对妊娠孕妇胎儿纤维连接蛋白、妊娠结局的影响

Effect of syphilis on fetal fibronectin and pregnancy outcomes of pregnant women

目的:分析合并梅毒对妊娠孕妇胎儿纤维连接蛋白(fFN)及妊娠结局的影响。方法:收集2015年1月至2017年6月佛山市南海区第五人民医院及广州市第一人民医院南沙医院收治且符合纳入条件的26例有先兆晚期流产及先兆早产迹象的梅毒孕妇作为梅毒组,选取同期佛山市南海区第五人民医院及广州市第一人民医院南沙医院收治的80例正常妊娠孕妇作为对照组,均采用调查表统计两组患者一般资料,并取阴道分泌物测定fFN阳性率,比较不同妊娠结局产妇fFN阳性情况。结果:梅毒组患者分娩孕周早于对照组,其既往不良妊娠、流产所占比例高于对照组,其差异具有统计学意义(P<0.05);梅毒组患者妊娠合并贫血所占比例高于对照组,其差异具有统计学意义(P<0.05);梅毒组患者fFN阳性率高于对照组,其差异具有统计学意义(P<0.05);梅毒组患者的胎儿窘迫发生率高于对照组,其差异具有统计学意义(P<0.05);梅毒组新生儿呼吸窘迫综合征发生率高于对照组,其差异具有统计学意义(P<0.05);fFN阳性梅毒孕妇早产发生率高于fFN阴性孕妇,其差异具有统计学意义(P<0.05);fFN阳性与阴性梅毒孕妇新生儿呼吸窘迫综合征发生率对比,其差异具有统计学意义(P<0.05)。结论:合并梅毒的妊娠期孕妇其fFN阳性率高,不良妊娠结局发生率高。

Objective： To analyze the effect of syphilis on fetal fibronectin （fFN） and pregnancy outcomes of pregnant women. Methods： A total of 26 pregnant women with syphilis who underwent late-term threatened abortion,had signs of threatened premature labor,met inclusion criteria and treated in Nansha Hospital of Guangzhou First People＇s Hospital and the 5 th People＇s Hospital of Nanhai District from January 2015 to June 2017 were included into the syphilis group. 80 normal pregnant women admitted to the two hospitals in the same period were selected as control group. The general data of both groups were statistically analyzed through questionnaires,the vaginal secretion was collected to determine the positive rate of fFN,and the positive rate of fFN was compared between women with different pregnancy outcomes. Results： The gestational weeks of syphilis group was earlier than control group. The proportions of women having previous adverse pregnancy and women undergoing abortion were higher than those in control group （P〈 0. 05）. The proportion of pregnant women with anemia and the positive rate of fFN in syphilis group were higher than those in control group （P〈 0. 05）. The incidence rates of fetal distress and neonatal respiratory distress syndrome in the syphilis group were higher than those in the control group （P〈 0. 05）.The incidence of premature delivery in pregnant women with fFN positive syphilis was higher than that in fFN negative pregnant women （P〈 0. 05）. There was no significant difference in the incidence of neonatal respiratory distress syndrome between fFN positive pregnant women and fFN negative pregnant women （P〉 0. 05）. Conclusions：The positive rate of fFN in pregnant women with syphilis is high,and the incidence of adverse pregnancy outcome is high.