盐酸达克罗宁胶浆应用在全麻气管插管及术中导尿的效果观察

Observation on the Effect of Dyclonine Hydrochloride Mucilage on Tracheal Intubation and Urethral Catheterization

目的:观察盐酸达克罗宁胶浆用于气管插管及术中导尿的效果。方法:选择2014年4月-2015年2月本院择期于全麻下行妇科手术的患者150例,将其按照随机数字表法平均分为A、B、C三组,各50例。A组:给予盐酸达克罗宁胶浆含服(5 m L)、气管润滑(2 m L)及术中导尿(3 m L);B组:给予利多卡因胶浆含服(5 m L)、导管润滑(2 m L)及术中导尿(3 m L);C组:给予0.9%氯化钠注射液含服、石蜡油润滑下气管导管并术中导尿。(1)记录患者体重、年龄、麻醉时间、手术时间以及不良反应。(2)记录术前(T_1)、插管前(T_2)、插管即刻(T_3)、插管后1 min(T_4)、插管后5 min(T_5),插管后10 min(T_6)的MAP及HR,并在T_2、T_4、T_5、T_6各个时点测定动脉血中肾上腺素(AD)及去甲肾上腺素(NA)的浓度。(3)术后患者进行RSS躁动评分。结果:三组患者年龄、体重、手术时间及麻醉时间比较,差异均无统计学意义(P>0.05)。A组不良反应例数为6例(12%),明显少于B、C组(P<0.05)。在T_1、T_2、T_3时点,三组MAP及HR比较,差异均无统计学意义(P>0.05);在T_4、T_5、T_6时点,A、B组比较,差异均无统计学意义(P>0.05),A、B组均低于C组,差异均有统计学意义(P<0.05)。在T_2、T_4时点,三组AD、NA比较,差异均无统计学意义(P>0.05),在T_5、T_6时点,A、B组均低于C组,差异均有统计学意义(P<0.05),而A组与B组比较,差异均无统计学意义(P>0.05)。A、B组的烦躁率均低于C组,差异均有统计学意义(字2=20.384、6.875,P<0.05);A组烦躁率低于B组,差异有统计学意义(字2=5.005,P<0.05)。结论:盐酸达克罗宁胶浆用于气管插管及术中导尿,不良反应少、尿管刺激小、安全性高,值得临床推广。

Objective：To observe the effect of Dyclonine Hydrochloride Mucilage for tracheal intubation and intraoperative catheterization.Method：150 patients selected for gynecological surgery under general anesthesia from April 2014 to February 2015 in our hospital were selected,and they were divided into group A,group B and group C on average according to the random number table,50 patients in each group.Group A：Dyclonine Hydrochloride Mucilage containing（5 m L）,tracheal lubrication（2 m L） and intraoperative catheterization（3 m L）;Group B：Lidocaine Gel containing（5 m L）,catheter lubrication（2 m L） and intraoperative catheter catheter（3 m L）;Group C：take 0.9% Sodium Chloride Injection,lubricate the tracheal catheter with paraffin oil and conduct urine during operation.（1）The patients＇ weight,age,anesthesia time,operation time and adverse reactions were recorded.（2）MAP and HR of pre-operative（T1）,pre-intubation（T2）,intubation instant（T3）,1 min after intubation（T4）,5 min after intubation（T5）,10 min after intubation（T6） were recorded.（3）Patients were given RSS restlessness score after surgery.Result：There were no significant differences in age,weight,operation time and anesthetic time among the three groups（P〉0.05）.The number of adverse reactions in group A was 6 cases（12%）,significantly lower than that in group B and C（P〈0.05）.At time points T1,T2 and T3,there were no statistically significant differences in MAP and HR among the three groups（P〉0.05）;at the time points of T4,T5 and T6,there were no statistically significant differences between group A and B（P〉0.05）,both group A and B were lower than group C,the differences were statistically significant（P〈0.05）.At time points T2 and T4,there were no statistically significant differences in AD and NA among three groups（P〉0.05）,at time points T5 and T6,both group A and group B were lower than group C,with statistically significant differences（P〈0.05）,but there was no statistically significant difference between the group A and B（P〉0.05）.The restlessness rate of group A and B were lower than that of group C,and the differences were statistically significant（X^2=20.384,6.875,P〈0.05）.The restlessness rate in group A was lower than that in group B,the difference was statistically significant（X^2=5.005,P〈0.05）.Conclusion：Dyclonine Hydrochloride Mucilage is used for endotracheal intubation and intraoperative catheterization,with less adverse reactions,less stimulation of the catheter and high safety,and is worthy of clinical promotion.