姑息性手术疗法在晚期胰腺癌患者治疗中的应用及对生存质量的影响研究

Application of Palliative Surgical Therapy in Treatment of Patients with Advanced Pancreatic Cancer and Its Effect on Quality of Life

目的:探究姑息性手术疗法在晚期胰腺癌患者治疗中的应用及对生存质量的影响。方法:选取2015年1月-2017年1月本院收治的晚期胰腺癌患者72例,按照随机数字表法将其分为研究组及常规组,各36例。研究组进行姑息性手术治疗,常规组进行常规化疗。比较两组患者治疗效果、治疗后1年的生存率及术后生存质量,并记录其治疗后不良反应情况。结果:研究组治疗后缓解率为27.78%,虽高于常规组的19.44%,但差异无统计学意义(P>0.05),但研究组控制率为66.67%,高于常规组的41.67%(X^2=4.531,P=0.033);至治疗后1年,研究组生存率为66.67%,显著高于常规组的41.67%(P<0.05);治疗后,研究组躯体功能、角色功能、认知功能、情绪功能、社会功能、整体功能评分均显著高于常规组,比较差异均有统计学意义(P<0.05);研究组不良反应发生率为16.67%,低于常规组的38.89%,比较差异有统计学意义(P<0.05)。结论:采用姑息性手术疗法对晚期胰腺癌患者进行治疗,与常规化疗相比,治疗效果、生存率及患者治疗后生存质量均有显著提高,且能够有效降低患者术后不良反应发生率,值得推广。

Objective：To explore the application of palliative surgical therapy in treatment of patients with advanced pancreatic cancer and its influence on the quality of life.Method：A total of 72 patients with advanced pancreatic cancer treated in our hospital from January 2015 to January 2017 were selected,according to random number table method,they were divided into study group and routine group,36 cases in each group.The study group received palliative surgical treatment,while routine group received conventional chemotherapy.The therapeutic effect,1 year survival after treatment and postoperative quality of life were compared between two groups,and the adverse reactions were recorded.Result：After treatment,the remission rate of study group was 27.78%,which was higher than 19.44% of routine group,but the difference was not statistically significant（P〉0.05）,however,the control rate of study group was 66.67%,which was higher than 41.67% of routine group（X^2=4.531,P=0.033）.In the 1 year after treatment,the survival rate of study group was 66.67%,which was significantly higher than 41.67% of routine group（P〈0.05）.After treatment,the scores of physical function,role function,cognitive function,emotional function,social function and overall function in study group were significantly higher than those of conventional group,the differences were statistically significant（P〈0.05）.The incidence of adverse reactions in study group was 16.67%,which was lower than 38.89% in routine group,the difference was statistically significant（P〈0.05）.Conclusion：Palliative surgical treatment of advanced pancreatic cancer patients,compared with conventional chemotherapy,the treatment effect,survival rate and quality of life after treatment have significantly improved,and can effectively reduce the incidence of postoperative adverse reactions,worthy of promotion.