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淋巴管浸润对上尿路尿路上皮癌患者预后的影响

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摘要 目的探讨淋巴管浸润对上尿路尿路上皮癌患者预后的影响。方法回顾性分析2013年9月至2015年9月郑州市第一人民医院收治的60例上尿路尿路上皮癌患者的临床资料。所有患者均接受手术治疗。根据术后病理检查淋巴管浸润情况将患者分为浸润组和非浸润组,其中浸润组19例,非浸润组41例。分析两组预后情况和患者术后复发的因素。结果中位随访时间为32个月,无死亡病例。淋巴管浸润组患者膀胱内复发10例,复发率为52.6%;非淋巴管浸润组患者膀胱内复发12例,复发率为29.3%。淋巴管浸润组复发率高于非淋巴管浸润组,差异有统计学意义(P<0.05)。Cox多因素分析结果显示淋巴管浸润(95%CI:1.098~2.894,P<0.05)、肿瘤分级(95%CI:1.043~2.541,P<0.05)和病理分期(95%CI:1.325~4.625,P<0.05)是上尿路尿路上皮癌无病生存率的独立影响因素。结论淋巴管浸润是上尿路尿路上皮癌预后不良的预测指标。淋巴管浸润、肿瘤分级较高以及病理分期较晚的患者具有更高的疾病复发风险,需接受密切随访和早期辅助治疗。
出处 《河南医学研究》 CAS 2018年第18期3298-3300,共3页 Henan Medical Research
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