氟哌噻吨美利曲辛片对不伴抑郁焦虑的腹泻型肠易激综合征的作用

Effect of Flupentixol and Melitracen Tablets in Treatment of Diarrhea-predominant Irritable Bowel Syndrome Non-accompanying with Depression and/or Anxiety Status

目的:观察氟哌噻吨美利曲辛片(黛力新)对不伴抑郁焦虑的腹泻型肠易激综合征的疗效。方法:选取2016年6月-2017年12月在笔者所在医院门诊就诊的腹泻型肠易激综合征并排除伴有抑郁和/或焦虑的患者80例,随机为治疗组、对照组,各组40例,治疗组给予黛力新1片,1次/d,对照组给予奥替溴铵40 mg/次,3次/d,疗程4周,记录不良反应,在药物治疗前后均记录肠道症状积分。结果:治疗组及对照组治疗前后症状积分差异有统计学意义(P<0.05),治疗后,治疗组症状积分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率均较低且差异无统计学意义(P>0.05)。结论:黛力新能显著改善不伴抑郁焦虑的腹泻型IBS患者症状。

Objective：To observe the clinical efficacy of Flupentixol and Melitracen Tablets（Deanxit） in diarrhea-predominant irritable bowel syndrome non-accompanying with depression and/or anxiety status.Method：80 diarrhea-predominant irritable bowel syndrome non-accompanying with depression and/or anxiety status were randomly allocated to the treatment group and the control group,the treatment group was given Deanxit,the control group was given Otilonium Bromide,two groups were under treatment for 4 weeks.The symptom scores of the patients before and after taking medicines and the adverse drug reactions were compared.Result：Differences of symptom scores were significant before and after treatment in the treatment group and the control group（P〈0.05）.The differences were also significant between the treatment group and the control group after treatment（P〈0.05）.The adverse drug reactions were low in the treatment group and the control group and there were no significant differences in the two groups（P〈0.05）.Conclusion：Deanxit can improve the symptoms in patients with diarrheapredominant irritable bowel syndrome non-accompanying with depression and/or anxiety status.