镍暴露相关的肺癌发生分子机制研究

Molecular Mechanism of Lung Cancer Related to Nickel Exposure

人体镍及其化合物暴露主要是通过吸入和摄入,已有的流行病学研究,肺癌发病率与镍元素相关暴露有显著的相关性。然而,镍及其化合物可通过多种途径从多个方面作用于组织细胞,诱导肺癌发生的分子机制尚不明确。本文主要对镍及其化合物影响细胞凋亡、自噬、侵袭和转移、增殖等方面进行综述,进一步促进与镍相关的肺癌致病机制的深入研究。

Exposure of human nickel and its compounds is mainly through inhalation and ingestion,and existing epidemiological studies have shown a significant correlation between lung cancer incidence and nickel-related exposure.However,nickel and its compounds can act on tissue cells in many ways through various ways,and the molecular mechanism of inducing lung cancer is still unclear.This review focuses on the effects of nickel and its compounds on apoptosis,autophagy, invasion and metastasis,and proliferation,and further promotes the in-depth study of the pathogenesis of nickel-related lung cancer.