SOD基因多态性与COPD易感性的Meta分析

Meta-analysis of SOD Gene Polymorphism and Susceptibility to COPD

目的系统评价SOD中SOD1+35A/C,SOD2 Val 16 Ala,SOD3 R213G基因多态性与慢性阻塞性肺疾病的相关性。方法检索CBM、CNKI、万方、VIP、EmBase和PubMed等中英文数据库,收集上述基因多态性与COPD的关系。采用Stata12.0软件进行统计分析,以病例组和对照组基因型分布比值比及其95%可信区间(95%CI)表示其关联强度。结果共纳入研究11项,其中病例组5915例,对照组96831例。Meta分析结果显示,SOD1+35A/C(CA vsAA:OR:1.31;95%CI:0.88~1.95)、SOD2Val 16 Ala (TC vsTT:OR:1.31;95%CI:0.88~1.95;CC vsTT:OR:0.93;95%CI:0.68~1.28)、SOD3 R213G (CA vsAA:OR,0.98;95%CI:0.63~1.53)基因多态性可能与COPD易感性无关,SOD3 R213G相关研究异质性较大(I2=68.8%),分组分析结果显示异质性主要来自于吸烟人群中。结论 SOD1+35A/C,SOD2 Val 16 Ala,SOD3 R213G基因多态性可能与COPD易感性无关,但在吸烟人群中SOD3 R213G多态性对COPD的影响需更多大样本的研究进一步证实。

Objective To assess the SOD SOD1＋35A/C,SOD2 Val 16 Ala,SOD3 R213G polymorphisms and chronic obstructive pulmonary disease relevance.Methods Chinese and English databases such as CBM,CNKI,Wanfang,VIP,EmBase and PubMed were searched to collect the relationship between the above gene polymorphisms and COPD.Statistical analysis was performed using Stata 12.0 software,and the correlation strength between the case group and the control group genotype distribution ratio and its 95% confidence interval（95%CI）.Results A total of 11 studies were included,of which 5915 were in the case group and 96831 in the control group.Meta-analysis results showed that SOD1＋35A/C（CA vsAA：OR：1.31;95%CI：0.88~1.95）,SOD2 Val 16 Ala（TC vsTT：OR： 1.31;95%CI：0.88~1.95;CC vsTT：OR：0.93;95%CI：0.68~1.28）,the polymorphism of SOD3 R213G（CA vsAA：OR,0.98;95%CI：0.63~1.53）may not be related to the susceptibility to COPD,and the heterogeneity of SOD3 R213G correlation study is large（I2=68.8%）.The results of the group analysis showed that the heterogeneity mainly came from the smoking population.Conclusion The SOD1 ＋35A/C, SOD2 Val 16 Ala,SOD3 R213G gene polymorphism may be unrelated to the susceptibility to COPD,but the effect of SOD3 R213G polymorphism on COPD in smokers requires further studies.