江苏省宿迁地区育龄妇女TORCH感染的调查分析

Nvestigation and Analysis of TORCH Screening for Women of Childbearing Age in Suqian,Jiangsu

目的回顾宿迁地区育龄妇女TORCH结果,分析TORCH阳性率和流行病学特点,为优生优育提供参考依据。方法选取2016年1月～2018年5月在宿迁市第一人民医院进行TORCH筛查的7 860例育龄妇女,应用酶联免疫方法检测anti-TORCH。结果 IgM抗体中,单纯疱疹病毒Ⅰ/Ⅱ(herpes simplex virus,Ⅰ/Ⅱ)检测出809例,阳性率为10.29%,明显高于其他三种病原体;不同季节中风疹病毒(rubellavirus,RUV)和HSVⅠ/Ⅱ好发于秋季,巨细胞病毒(cytomegalovirus,CMV)好发于春、秋两季;在不同年龄组中CMV在35岁以上妇女中阳性率最高(31/758,4.09%),与其他组相比,差异具有统计学意义(χ~2=4.12,P=0.04),HSVⅠ/Ⅱ在35岁以上妇女中阳性率最低(48/758,6.33%),与其他组相比,差异具有统计学意义(χ~2=14.47,P=0.00);农村人口中TOX,CMV和HSVⅠ/Ⅱ抗体阳性率明显高于城市,差异具有统计学意义(χ~2=10.39,6.31,4.84,均P<0.05);IgG抗体中,TOX检出率最低,阳性率为3.27%(257/7 860),明显低于RUV,CMV和HSVⅠ/Ⅱ(78.89%,82.82%和65.95%)。结论宿迁地区育龄妇女TORCH筛查结果阳性率较低,但防控形势依然严峻,仍需积极做好预防措施,提高优生优育质量,改善人口素质。

Objective To review the TORCH results of women of childbearing age in Suqian area and analyze the positive rate and epidemiological characteristics of TORCH,so as to provide reference for eugenics and good childbearing. Methods Se lected 7 860 women from January 2016 to May 2018 in the First Hospital of Suqian for TORCH. AntfTORCH was detected by ELISA. Results Among the IgM antibodies, 809 cases were detected by HSV Ⅰ/Ⅱ, the positive rate was 10.29 %, which was significantly higher than that of the other three pathogens, in different seasons RUV and HSV Ⅰ/Ⅱ were predominant in autumn and CMV was predominant in spring and autumn. In different age groups,the positive rate of CMV was the highest in women over 35 years old （31/758,4.09%）, and the difference was significant compared with other groups, statistical sig nificance （x2=4.12, P=0.04）. The lowest positive rate of HSV Ⅰ/Ⅱ in women over 35 years old （48/758,6.33%）, corn pared with other groups, the difference was statistically significant （χ^2= 14.47, P 0.00）. The positive rate of TOX, CMV and HSV Ⅰ/Ⅱ antibodies in rural population was significantly higher than that in urban population, and the difference was statistically significant （χ^2= 10.39,6.31,4. 84, all P〈0.05）. Among the IgG antibodies, TOX was the lowest, positive rate 3.27%,257/7 860,significantly lower than RUV,CMV and HSV Ⅰ/Ⅱ （78.89%,82.82% and 65.95%）. Conclusion The positive rate of TORCH screening among women of childbearing age in Suqian area was low, but the situation of prevention and control is still grim. It is still necessary to take effective preventive measures to improve the quality of eugenic and child bearing and improve the quality of population.