微生态制剂在肝硬化自发性细菌性腹膜炎治疗中的作用

The Role of Probiotics in the Treatment of Spontaneous Bacterial Peritonitis in Cirrhosis

目的分析微生态制剂在治疗肝硬化自发性细菌性腹膜炎(SBP)患者中的作用。方法将2017年11月—2018年3月我院收治的90例肝硬化合并SBP患者作为研究对象,将其随机分为实验组(45例)和对照组(45例)。两组患者采用抗感染、利尿、保肝的常规性治疗,实验组在此基础上,增加使用双歧杆菌活菌制剂。结果治疗后,实验组在腹胀、腹痛消失的时间以及腹部压痛消失、腹水WBC和体温恢复正常的时间,与对照组相比明显缩短,血蛋白(ALB)、凝血酶活动度(PTA)升高,差异具有统计学意义(P <0.05)。结论微生态制剂能够对肠道菌进行调解,减少肠源性毒素的产生和血浆炎性细胞因子的表达,能辅助治疗肝硬化自发性细菌性腹膜炎。

Objective To analyze the role of microecological agents in the treatment of patients with spontaneous bacterial peritonitis （SBP） of liver cirrhosis. Methods 90 cases of liver cirrhosis combined with SBP in our hospital from November 2017 to March 2018 were studied and randomly divided into experimental group （45 cases） and control group （45 cases）. The two groups were treated with conventional treatment of anti infection, diuresis and liver protection, and the experimental group added Bifdobacterium viable preparations on this basis. Results After treatment, the time of abdominal distention, abdominal pain disappearing, abdominal tenderness disappearing, ascites WBC and body temperature returning to normal in the experimental group were signifcantly shorter than those in the control group, and blood protein （ALB） and thrombin activity （PTA） were increased, the difference was statistically significant （P 〈 0.05）.Conclusion Microecological agents can regulate intestinal bacteria, reduce the production of enterotoxin and the expression of infammatory cytokines in plasma, and assist in the treatment of spontaneous bacterial peritonitis of cirrhosis.