武威市大骨节病与骨关节炎患者四种元素及炎症因子水平差异分析

Analysis the difference of four elements and inflammatory factors in patients with Kashin-Beck disease and osteoarthritis in Wuwei City

目的分析武威市大骨节病与骨关节炎患者四种元素及炎症因子水平的差异。方法选择2016年3月至2018年1月期间,在本院接受诊治的75例大骨节病及骨关节炎患者,并选取同期健康体检志愿者30例为研究对象,其中44例大骨节病(Kaschin-Beck disease,KBD)为KBD组,31例骨关节炎(osteoarthritis,OA)为OA组,30例健康体检志愿者为对照组。比较三组血清中硒、钙、碘、镉等元素水平,并检测三组IL-6和TNF-α含量。结果 KBD组Se含量明显低于OA组和对照组,同时KBD组Ca含量显著高于OA组和对照组(P<0.05),但是三组Zn含量和Fe含量相比差异无统计学意义(P>0.05)。KBD组患者血清IL-6和TNF-α水平明显低于OA组(P<0.05),但KBD和OA两组血清IL-6和TNF-α水平明显高于对照组(P<0.05)。通过Spearman相关性分析,75例大骨节病及骨关节炎患者血清IL-6及TNF-α水平与微量元素Se含量呈显著正相关(P<0.05),而IL-6及TNF-α水平与Ca元素含量呈显著负相关(P<0.05)。结论武威市地区大骨节病与骨关节炎患者硒、钙含量存在明显差异,同时骨关节炎患者的炎症因子水平高于大骨节病患者,且炎症因子与硒、钙元素含量存在相关性。

Objective To analyse the difference of 4 kinds elements and inflammatory factors level between Kashin-Beck disease and Osteoarthritis in Wuwei City. Methods From March 2016 to January 2018, 75 cases of patients with Kaschin-Beck disease and osteoarthrits were treated in our hospital, and 30 case of healthy volunteers, considered as subject investigated. 44 cases of Kaschin-Beck disease （KBD group）, 31 cases of osteoarthritis （OA group）and 30 cases of healthy volunteers as control group. The levels of selenium, calcium, iodine and cadmium in serum of the three groups were compared, and the contents of IL-6 and TNF-α in the three groups were detected. Results The content of Se in KBD group was significantly lower than that in OA group and control group（ P 〈0.05）, and the content of Ca in KBD group was significantly higher than that in OA group and control group （ P 〈0.05）. But there was no significant difference in Zn content and Fe content between the three groups （ P 〉0.05）. The levels of serum IL-6 and TNF-α in KBD group were significantly lower than those in OA group （ P 〈0.05）, but the serum IL-6 and TNF-α in KBD group and OA group were significantly higher than those in control group （ P 〈0.05）. There were the significant positive correlation between the levels of serum IL-6, TNF-α and trace elements se in 75 patients with Kaschin-Beck disease and osteoarthritis by spearman correlation analysis （ P 〈0.05）. And the level of IL-6 and TNF-αwere negatively correlated with the content of Ca （ P 〈0.05）. Conclusion There was significant difference in selenium and calcium content between patients with Kashin-Beck disease and osteoarthritis in Wuwei City, and the level of inflammatory factors in patients with osteoarthritis was higher than that in patients with Kaschin-Beck disease. Inflammatory factors were correlated with the contents of selenium and calcium.