抗结核药药疹与斑贴试验

Drug Rash by Anti-tuberculosis Drugs and Patch Test

结核病是一种常见的慢性呼吸道传染性疾病,其治疗周期长,用药比较复杂,抗结核药物不良反应较多,引起的药疹也比较常见,如何确定致敏药物对临床诊治有重要意义。寻找药物致敏原在临床中一直很受关注,检测方法没有统一标准,斑贴试验是检测迟发型过敏反应致敏原的主要手段,进行药物斑贴试验的目的是找出可疑致敏药物,为临床诊治提供依据,而且药物斑贴试验在临床应用中相对比较安全,操作简便,结核病患者常为联合用药,斑贴试验可以同时检测多种药物,在临床药疹的诊断中应用越来越广泛,在对抗结核药引起的药疹的诊治中能够提供重要的依据。

Tuberculosis （TB） is a common chronic respiratory infectious disease, the treatment cycle is long, and the anti-tuberculosis drug is more complex. There is more adverse reactions of anti-tuberculosis drugs, and drug eruption is more common caused by anti-tb drugs. How to determine the sensitization drugs for clinical diagnosis and treatment is important. Looking for drugs allergen has been very popular in the clinical, there is no unified standard analytical methods. Patch test is the principal means of delayed allergy. The purpose of drug patch test is to identify suspicious sensitization drugs, provide the basis for clinical diagnosis and treatment, and drug patch test is relatively safe and simple in clinical application, The drugs of TB patients are often combination, patch test can detect a variety of drugs, it is more and more widely applied in the clinical diagnosis of drug eruption, it can provide important basis in the diagnosis and treatment of drug eruption.