曲唑酮治疗酒精戒断后焦虑的临床疗效研究

Evaluation of Efficacy and Safety of Trazodone Treatment for Anxiety After Alcohol Withdrawal

目的探讨使用曲唑酮治疗酒依赖患者在戒酒后出现焦虑的疗效及安全性。方法将符合条件的64例酒精戒断后伴发焦虑患者随机分成两组,分别给予曲唑酮联合常规戒酒治疗(实验组,n=32)和常规戒酒治疗(对照组,n=32),进行8周的系统治疗,使用汉密尔顿焦虑量表(HAMA)、密西根酒精依赖调查表(MAST),以副反应量表(TESS)和有关的实验室检查评定药物副反应。结果实验组在治疗后第2、4、8周末HAMA的评分均低于对照组,差异有统计学意义(P<0.05);实验组在治疗后第4、8周末MAST的评分均低于对照组,差异有统计学意义(P<0.05)。结论曲唑酮治疗酒依赖患者酒精戒断后焦虑情绪安全有效,并能明显降低饮酒欲望,强化酒依赖治疗效果。

Objective To evaluate the efficacy and safety of trazodone treatment for anxiety after alcohol withdrawal. Methods 64 alcohol abuse patients with anxiety after alcohol withdrawal were randomly divided into intervention group （n=32） and control group （n=32）. The intervention group was given trazodone and regular abstinence treatment for alcohol dependence. The control group was given the regular abstinence treatment only. The course were both 8 weeks. By using HAMA、MAST and TESS scale, the effcacy and safety of trazodone treatment were evaluated at the baseline and at the end of 1th, 2nd, 4th, 8th week respectively. Results The HAMA score of trazodone group was significantly lower than the control one at the end of the 2nd, 4th, 8th week, the difference was statistically significant （P〈0.05）. The MAST score of the trazodone group was signifcantly lower than the control group at the end of the 4th, 8th week, the difference was statistically signifcant （P〈0.05）. Conclusion Trazodone is safe and effective for anxiety after alcohol withdrawal, and it can obviously reduce the desire for alcohol and strengthen the effect of abstinence treatment for alcohol dependence.