摘要
目的观察解毒消瘰方治疗非霍奇金淋巴瘤的临床疗效及其对Th17/Treg和相关因子水平的影响。方法按照治疗方案不同将60例非霍奇金淋巴瘤病患者分为对照组和治疗组,各30例。对照组应用常规治疗,治疗组在对照组基础上加用解毒消瘰方,连用4个疗程。比较两组总缓解率、Th17/Treg细胞及相关细胞因子等情况。结果两组总缓解率差异无统计学意义,治疗组Th17细胞百分率及IL17水平较对照组高(均P <0.05);Treg细胞百分率及TGF-1水平较对照组低(均P <0.05)。结论解毒消瘰方治疗非霍奇淋巴瘤可改善临床症状,降低Treg细胞百分率及TGF-1水平,升高Th17细胞百分率及IL17水平。监测外周血Th17/Treg及其相关因子水平的变化对非霍奇金淋巴瘤预后判定可能有重要的临床意义。
Objective To observe the clinical effect of Jieduxiaouo recipe on non-hodgkin lymphoma. Methods Sixty patients with non-Hodgkin lymphoma were randomly divided into control group and treatment group with 30 cases in each group. The control group was treated with routine treatment, while the treatment group was treated with Jiedu xiaoluo recipe on the basis of the control group. After four courses of treatment, the total remission rate, Th17/treg cells and related cyto- kines of both groups were observed. Results Overall remission rate of treatment and control group was 86.67% and 83.33%, respectively. The percentage of Th17 cells and the level ofIL 6 in the treatment group were significantly higher than those in the control group ( allP 〈 0.05). Treg cell percentage and TGF-β1 level were significantly lower than those of the control group ( all P 〈 0.05). Conclusion Jiedu xiaoluo recipe can improve clinical symptoms, reduce treg cell percentage and TGF-β 1 level, increase Thl 7 cell percentage and IL 17 level in treating non-hodgkin lymphoma.
作者
许晓娜
张宇
宋岩松
李航超
周郁鸿
XU Xiaona;ZHANG Yu;SONG Yansong;LI Hangchao;ZHOU Yuhong(The First Affiliated Hospital to Zhejiang Chinese Medical University Hangzhou 310053,Zhejiang,China)
出处
《现代实用医学》
2018年第9期1135-1137,共3页
Modern Practical Medicine
基金
国家中医临床研究基地业务建设第二批科研专项(2015H0105)
浙江省医药卫生科技计划项目(2017KY116)
关键词
非霍奇金淋巴瘤
解毒消瘰方中医药
Non-hodgkin lymphoma
Jieduxiaouo recipe
Traditional Chinese Medicine