食管鳞癌细胞中程序性细胞死亡因子4与核转录因子的表达

Expression of Programmed Cell Death Factor 4 and Nuclear Transcription Factor in Esophageal Squamous Cell Carcinoma

目的:探讨程序性细胞死亡因子4(PDCD4)与核转录因子(NF-κB)在食管鳞癌中的表达及其与临床病理参数的关系。方法:应用免疫组化Evision法检测PDCD4、NF-κB在58例食管鳞癌组织及配对癌旁正常食管黏膜组织中的表达,分析PDCD4、NF-κB在食管鳞癌中的表达与临床病理参数的关系、食管鳞癌组织中PDCD4及NF-κB表达的关系。结果:PDCD4蛋白在食管鳞癌细胞中的阳性率低于正常组织,差异具有统计学意义(P <0. 01); NF-κB蛋白在食管鳞癌中的阳性率高于正常组织,差异具有统计学意义(P <0. 01);在食管鳞癌中,PDCD4的表达与淋巴结转移有关(P <0. 01),NF-κB表达与淋巴结转移及浸润深度有关(P <0. 01); PDCD4与NF-κB在食管鳞癌中的表达无相关性(P> 0. 05)。结论:PDCD4与NF-κB的异常表达可能与食管鳞癌的发生发展密切相关。

Objective：To investigate the expression of programmed cell death factor 4 （PDCD4） and nuclear transcription factor （NF-κB） in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters. Methods： Expression of PDCD4 and NF-κ B in 58 cases of esophageal squamous cell carcinoma and adjacent normal esophageal mucosa was detected by immunohistochemical Evision. The relationship between the expression of PDCD4 and NF-κB in esophageal squamous cell carcinoma and clinicopathological parameters, and the expression of PDCD4 and NF-κB in esophageal squamous cell carcinoma were analyzed. Results： The positive rate of PDCD4 protein in esophageal squamous cell carcinoma was lower than that in normal tissues, and the difference was statistically significant （ P 〈0.01）. The positive rate of NF-κB protein in esophageal squamous cell carcinoma was higher than that in normal tissue, and the difference was statistically significant （ P 〈0.01）. In esophageal squamous cell carcinoma, expression of PDCD4 was associated with lymph node metastasis （ P 〈0.01）, and expression of NF-κB was related to lymph node metastasis and depth of invasion （ P 〈0.01）. There was no correlation between the expression of PDCD4 and NF-κB in esophageal squamous cell carcinoma（ P 〉0.05）. Conclusion： The abnormal expression of PDCD4 and NF-κB is closely related to the occurrence and development of esophageal squamous cell carcinoma.