期刊文献+

氨磺必利联合MECT对难治性精神分裂症患者PNASS评分及生活质量的影响 被引量:9

下载PDF
导出
摘要 目的分析氨磺必利联合无抽搐电休克(MECT)对难治性精神分裂症患者阳性和阴性症状评分(PNASS)及生活质量的影响。方法选取2016年2月~2017年2月我院收治的82例难治性精神分裂症患者,随机数字表法分为观察组和对照组各41例。对照组予以氨磺必利治疗,观察组予以氨磺必利+MECT治疗,两组均治疗2个月。观察两组治疗效果、PNASS评分、生活质量评分(GQOL-74)及不良反应发生情况。结果观察组治疗有效率为87.80%,高于对照组的60.98%,差异有统计学意义(P<0.05);观察组治疗后2个月GQOL-74评分显著高于对照组,PANSS评分显著低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率的4.87%与对照组的14.63%比较,差异无统计学意义(P>0.05)。结论联合氨磺必利与MECT治疗难治性精神分裂症患者可提高治疗效果,降低PANSS评分,提升生活质量。
作者 白倩
出处 《现代诊断与治疗》 CAS 2018年第16期2558-2560,共3页 Modern Diagnosis and Treatment
  • 相关文献

参考文献7

二级参考文献70

  • 1中华医学会精神科分会.中国精神疾病分类与诊断标准(CCMD-3)[M].3版.济南:山东出版社,2001:87-89.
  • 2Dos Santos Pereira JN, Tadjerpisheh S, Abu Abed M, et al. The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family [ J]. AAPS J, 2014, 16 (6) :1247 - 1258.
  • 3Hou YC, Lai CH. The relief of leukocytopenia within 1 month after switching risperidone to amisulpride [ J ]. J Neuropsychiatry Clin Neurosei ,2014,26 (3) :40 - 41.
  • 4Mandal N, Singh OP, Sen S, et al. Extrapyramidal side effects with low doses of amisulpride [ J ]. Indian J Psychiatry, 2014,56 ( 2 ) : 197 - 199.
  • 5Csomor PA, Preller KH, Geyer MA, et al. Influence of aripiprazole, risperidone, and amisulpride on sensory and sensorimotor gating in healthy low and high gating" humans and relation to psychometry [ J ]. Neuropsychopharmacology, 2014, 39(10) :2485 -2496.
  • 6Levine SZ, Leueht S. Treatment response heterogeneity in the predominant negative symptoms of schizophrenia: analysis of amisulpride vs placebo in three clinical trials [J]. Schizophr Res,2014,156( 1 ) :107 - 114.
  • 7Jang YJ, Jeong TC, Noh K, et al. Prandial effect on the systemic exposure of amisulpride [ J ]. Arch Pharm Res, 2014,37(10) :1325 - 1328.
  • 8GOMEZ-DURAN E L, MARTIN-FUMADO C, HURTADO- RUIZ G. Clinical and epidemiological aspects of suicide in patients with schizophrenia[ J] .Actas Esp Psiquiatr, 2012, 40(6) : 333-345.
  • 9TAKEUCHI H,SUZUKI T, REMINGTON G, et al.Effects of risperidone and olanzapine dose reduction on cognitivefunction in stable patients with schizophrenia: an open- label, randomized, controlled, pilot study [ J ]. Schizophr Bull, 2013,39 ( 5 ) : 993-998.
  • 10UKPONG D I, MAKANJUOLA R 0 A, MORAKINYO O.A controlled trial of modified electroconvulsive therapy in schizophrenia in a Nigerian teaching hospital[ J] .West Afr J Med, 2002,21 ( 3 ) : 237-240.

共引文献130

同被引文献64

引证文献9

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部