卡前列素氨丁三醇注射液用于宫缩乏力性产后出血治疗临床研究

Clinical study on the effect of carboprost tromethamine injection in the treatment of postpartum hemorrhage due to uterine atony

目的:对在宫缩乏力行产后出血病症上采用卡前列素氨丁三醇注射液的临床疗效进行探究。方法:择取2014年2月至2017年2月于延安市人民医院妇产科接受治疗的80例宫缩乏力行产后出血女性进行回顾分析。依据随机数字表法及对每位宫缩乏力性产后出血女性所采用治疗方案的不同,将其均分至常规按摩联合卡贝缩宫素药物治疗的常规组,和在常规组基础上加以卡前列素氨丁三醇注射液治疗的观察组,将常规用药方案同注射卡前列素氨丁三醇药物治疗对宫缩乏力性产后出血产妇出血量以及不良反应的影响差异进行对比。结果:常规、观察两组产妇临床总有效率分别为60%(24/40)、95%(38/40),差异具有统计学意义(P <0. 05)。同时,无论是在用药后第三产程出血量方面,还是在其子宫出血率、切除率方面,采用卡前列素氨丁三醇注射液的观察组均明显优于常规组,差异具有统计学意义(P <0. 05)。而两组产妇在不良反应发生率方面差异无统计学意义(P> 0. 05)。结论:对于宫缩乏力性产后出血实施卡前列素氨丁三醇注射液进行治疗能够显著减少产后出血量、降低子宫切除率与出血率,临床效果显著,值得推广。

Objective：To further study the effect of carboprost tromethamine injection in the treatment of postpartum hemorrhage due to uterine atony. Methods ： The clinical data of 80 patients with postpartum hemorrhage due to uterine atony in Yan＇an People＇s Hospital from February 2014 to February 2017 was retrospectively analyzed. According to the random number table method and different treatment received, the patients were divided into the convention group and observation group. The convention group received conventional massage combined with carbetocin while the observation group received carboprost tromethamine injection on the basis of the convention group. The amount of blood loss and adverse reactions were compared between the two groups. Results ： The total effective of the convention group and observation group was 60% （24/40） and 95% （38/40） respectively, with statistically significant difference （ P 〈 0. 05 ）. The observation group was better than the convention group in the amount of bleeding during the third stage of labor, incidence of bleeding and hysterectomy rate, all with statistically significant differences （ P 〈 0. 05 ）. Difference in the incidence of adverse reactions was not statistically significant （ P 〉 0. 05 ）. Conclusions ： Carboprost tromethamine injection has remarkable effect in the treatment of postpartum hemorrhage due to uterine atony, which can significantly reduce the amount of postpartum hemorrhage, hysterectomy rate and bleeding rate, hereby worthy of promotion.