外周血Th17/Treg细胞对花粉症患者病情发作的影响

Effect of peripheral blood Th17/Treg cells on the onset of disease in patients with hay fever

目的探索外周血T辅助细胞17(Th17)、调节性T细胞(Treg)、Th17/Treg细胞对花粉症患者病情发作的影响。方法选取2015-02~2018-02于延安大学附属医院接受治疗的86例花粉症患者作为观察组,并随机选取同期于本院接受体检的86例健康体检者作为对照组。观察组按照是否在非花粉季节(11~12月份)发作将患者分为非发作期组和发作期组,收集患者基线资料并进行对比,采集患者外周血并检测Th17、Treg、Th17/Treg指标水平。结果发作期组与非发作期组对比,性别、病程、花粉遗传史数据对比不具有统计学差异(P> 0. 05),居住地域、城乡情况对比具有统计学意义(P <0. 05)。观察组Th17细胞指标水平为(0. 43±0. 03),显著高于对照组(0. 26±0. 01),另外Treg(6. 46±1. 38)、Th17/Treg(19. 22±3. 67)指标水平明显低于对照组Treg(6. 46±1. 38)和Th17/Treg(40. 32±11. 35),数据具有统计学意义(P <0. 05)。非发作期组Th17指标水平为(0. 37±0. 03),显著低于发作期组(0. 49±0. 05),另Treg(7. 69±2. 11)、Th17/Treg(5. 23±1. 46)指标水平明显高于发作期组Treg(27. 41±9. 79)、Th17/Treg(11. 03±3. 14),数据具有统计学意义(P <0. 05)。结论花粉症患者病情发作与地域及城乡位置具有相关性,花粉症患者发病时Th17、Treg、Th17/Treg指标水平变化较健康人群差异较为明显,同时发作期花粉症患者与非发作期花粉症患者存在差异。

Objective To explorethe effects of peripheral blood T helper cells 17 （Th17）, regulatory T cells （Treg） and Th17/Treg cells on the onset of disease in patients with hay fever.Methods 86 patients from February 2015 to February 2018 were treated in our hospital as the observation group, and 86 healthy physical examination subjects were selected as the control group at random. In the non-pollen season （11~12 month）, the observation group divided the patients into non-episodes and episodes, collected the patients’ baseline data and compared them, collected peripheral blood and detected the levels of Th17, Treg and Th17/Treg.Results Compared with the non-attack stage, the sex, the course of disease and the genetic history of pollen were not statistically significant （P〉0.05）, and the living area and the urban and rural situation were statistically significant （P〈0.05）.The level of Th17 cell index in the observation group was （0.43±0.03）, which was significantly higher than that of the control group of （0.26±0.01）, and the level of Treg （6.46±1.38） and Th17/Treg （19.22±3.67） was significantly lower than that of the control group of （6.46±1.38） and Th17/Treg of （40.32±11.35）, and the data were statistically significant （P〈0.05）.The level of Th17 index in non-episodes group was （0.37 ± 0.03）, significantly lower than that in the attack group （0.49 ± 0.05）, the other Treg （7.69±2.11） and Th17/Treg （5.23 ± 1.46） were significantly higher than that in the attack group Treg （27.41±9.79） and Th17/Treg （11.03＋3.14）, and the data were statistically significant （P〈0.05）.Conclusion The incidence of hay disease is related to the region and the location of urban and rural areas. The changes of Th17, Treg and Th17/Treg in the patients with hay fever are more obvious than those of the healthy population.