坏死性小肠结肠炎新生儿肠道菌群变化研究进展

Research progress in changes of intestinal flora in neonatal necrotizing enterocolitis

新生儿坏死性小肠结肠炎（NEC）是最常见的新生儿胃肠道急症，早产儿发生率高，其发病机制仍不明确。近年米，肠道菌群在NEC病理学进展中的关键作用受到关注。技术层面上，高通量测序、荧光原位杂交、变性梯度凝胶电泳等分子技术的普及和深入发展也为进一步探究NEC与肠道菌群之间的相关性提供了有利条件。现就NEC病理学进展与肠道菌群变化之间的关系进行综述。

Neonatal necrotizing enterocolitis（NEC） is the most common neonatal gastrointestinal emergency, and its pathogenesis is still not clear. In recent years,intestinal flora has been keenly concerned about its pivotal role in the progress of NEC pathology. At the technical level,the popularity and in - depth development of high throughput sequencing,fluorescence in situ hybridization and polymerase chain reaction -denaturing gradient gel electrophoresis are also favorable conditions for further study of the correlation between NEC and intestinal flora. Now,the relationship between the pathological developnlent of NEC and intestinal flora was reviewed.