摘要
目的:探讨环孢素A联合科素亚治疗进展性IgA肾病的临床疗效。方法:将64例进展性IgA肾病患者纳入研究,分为对照组与观察组各32例。对照组采用单用科素亚治疗,观察组采用环孢素A联合科素亚治疗,观察两组患者治疗后总有效率、24h尿蛋白定量、血浆白蛋白、血肌酐变化,同时观察不良反应。结果:观察组患者治疗总有效率明显高于对照组(96.88%VS81.25%),P<0.05。治疗前,疗效指标比较差异均无统计学意义,P>0.05;治疗后,观察组24h尿蛋白定量及血肌酐水平均优于对照组,P<0.05。结论:环孢素A联合科素亚治疗进展性IgA肾病治疗效果良好。
Objective: To explore the clinical effect of cyclosporine A combined with losartan in the treatment of progressive IgA nephropathy. Methods: 64 patients with advanced IgA nephropathy treated in a hospital were divided into control group and observation group with 32 cases in each group. Control group only used losartan in the treatment,the observation group used the cyclosporine A combined with losartan treatment. The total effective rate and curative effect of the two groups were observed. Results: The total effective rate of the observation group was significantly higher than that of the control group (96.88%VS81.25%)( P 〈0.05). Before treatment, there was no significant difference in curative effect index( P 〉0.05). After treatment, the curative effect index of the observation group is better than that of the control group( P 〈 0.05 ). Conclusion: Progressive IgA nephropathy is treated with cyclosporine A combined with losartan, the treatment efficiency is significant.
作者
郑设锋
赵章健
卢蝉
陈法东
薛增奇
Zheng Shefeng(Department of Nephrology,No.3 Affiliated Hospital of Wenzhou Medical University,Rui'an 32520)
出处
《数理医药学杂志》
2018年第10期1529-1530,共2页
Journal of Mathematical Medicine