头颈部肿瘤患者放射性口咽炎防治的研究进展

Research Progress in Radiation-Induced Oropharyngeal Mucositis in Head and Neck Cancer Patients

头颈部肿瘤是临床常见的肿瘤之一,综合治疗是头颈部肿瘤的主要治疗方式。放疗在头颈部肿瘤治疗中发挥重要作用,常见不良反应放射性口咽黏膜炎(RIOM)是影响患者生活质量,导致治疗中断及影响预后的主要原因之一。适当的预防和治疗有助于减轻RIOM的严重程度,从而提高患者的生存质量。提高患者对治疗的依从性可能有助于更好地控制疾病和延长患者生存时间。目前RIOM尚无特效防治方法,寻找理想的防治手段一直是肿瘤科医师的热点课题。近年来使用生长因子、氨磷汀、谷氨酰胺、锌剂等药物防治RIOM成为该领域的研究热点,而最佳药物、药物途径、药物标准剂量等仍存在争议。

Head and ned neck tunmors are one of the common cancerds in clinical.Multi-modaliy treatment is the main treat-ment for head neck tunmors,and radiotherapy plays an important role in the treatment.One of the most commonly seenadvrse effects of radiotherapy is radiation-induceal mucisitis（RTOM）which affects the life qualiy of the parients,leads to the interruption of treatment,and impacts the prognosis.Adequate prophylaxis and treatment may reduce the severity of RIPM and improve the survival quality of the patients.Improving patient compliance with treatment may helpcotrol control disease and prolong survival time.At prsesent,there is no special effective method for the prevention and control of RIOM.The search for effective treatment has always been a hot topic for oncologists.In recent years,the study focuses are drugs such as growth factors,glutamine,amifostine,zinc and so on for the prevention and treatment of RIOM.Nevertheless,the optimal drug,administration route,and standard dose are still comtroversial.